The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients' with low vitamin D

Ruslinda Mustafar, Rozita Mohd, Norazinizah Ahmad Miswan, Arba'ayah Bain, Rizna Abdul Cader, Abdul Halim Abdul Gafor, Marlyn Mohammad, Shamsul Azhar Shah, Nor Azmi Kamaruddin, Norella C T Kong

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Abstract

Introduction: Chronic kidney disease (CKD) patients' are at risk of low vitamin D and chronic inflammation. We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum; interleukin-6 (IL-6), interleukin-10 (IL-10) and highly sensitive C-reactive protein (hs-CRP). Material and methods: A prospective randomized study in CKD stages 2-4 with serum 25-hydroxyvitamin D (25-OHD) levels < 30 ng/ml. Patients were randomized into the Vitamin D + Calcium (Vitamin D+C) or Calcium group. Serums were analyzed at baseline, week 6 and 12. Results: Fifty patients, median age of 53 (13.5) years were recruited. Their median IL-10 was 13.35 (25.22) pg/ml. At week 12, serum IL-6 was reduced in both groups (p = 0.001), serum IL-10 was maintained in the Vitamin D + C group (p = 0.06) and was reduced in the Calcium group (p = 0.001). CKD-diabetic patients had reduced serum IL-6 in both study groups (p = 0.001) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts (p = 0.005). Serum IL-10 was reduced in the Calcium group (p < 0.05) whereas serum 25-OHD rose in both groups, regardless of their diabetic status (p < 0.05). Conclusions: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalCentral European Journal of Immunology
Volume39
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Calcium Carbonate
Calcitriol
Chronic Renal Insufficiency
Vitamin D
Biomarkers
Interleukin-10
Serum
Interleukin-6
Calcium
Dilatation and Curettage
Vitamins
C-Reactive Protein
Prospective Studies
Inflammation

Keywords

  • Calcitriol
  • Chronic kidney disease
  • Diabetes
  • Inflammation
  • Vitamin D

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

@article{462cb57ad1c6430faa83beaa05bea523,
title = "The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients' with low vitamin D",
abstract = "Introduction: Chronic kidney disease (CKD) patients' are at risk of low vitamin D and chronic inflammation. We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum; interleukin-6 (IL-6), interleukin-10 (IL-10) and highly sensitive C-reactive protein (hs-CRP). Material and methods: A prospective randomized study in CKD stages 2-4 with serum 25-hydroxyvitamin D (25-OHD) levels < 30 ng/ml. Patients were randomized into the Vitamin D + Calcium (Vitamin D+C) or Calcium group. Serums were analyzed at baseline, week 6 and 12. Results: Fifty patients, median age of 53 (13.5) years were recruited. Their median IL-10 was 13.35 (25.22) pg/ml. At week 12, serum IL-6 was reduced in both groups (p = 0.001), serum IL-10 was maintained in the Vitamin D + C group (p = 0.06) and was reduced in the Calcium group (p = 0.001). CKD-diabetic patients had reduced serum IL-6 in both study groups (p = 0.001) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts (p = 0.005). Serum IL-10 was reduced in the Calcium group (p < 0.05) whereas serum 25-OHD rose in both groups, regardless of their diabetic status (p < 0.05). Conclusions: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics.",
keywords = "Calcitriol, Chronic kidney disease, Diabetes, Inflammation, Vitamin D",
author = "Ruslinda Mustafar and Rozita Mohd and Miswan, {Norazinizah Ahmad} and Arba'ayah Bain and {Abdul Cader}, Rizna and {Abdul Gafor}, {Abdul Halim} and Marlyn Mohammad and Shah, {Shamsul Azhar} and Kamaruddin, {Nor Azmi} and Kong, {Norella C T}",
year = "2014",
doi = "10.5114/ceji.2014.43729",
language = "English",
volume = "39",
pages = "236--242",
journal = "Central-European Journal of Immunology",
issn = "1426-3912",
publisher = "Termedia Publishing House Ltd.",
number = "2",

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TY - JOUR

T1 - The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients' with low vitamin D

AU - Mustafar, Ruslinda

AU - Mohd, Rozita

AU - Miswan, Norazinizah Ahmad

AU - Bain, Arba'ayah

AU - Abdul Cader, Rizna

AU - Abdul Gafor, Abdul Halim

AU - Mohammad, Marlyn

AU - Shah, Shamsul Azhar

AU - Kamaruddin, Nor Azmi

AU - Kong, Norella C T

PY - 2014

Y1 - 2014

N2 - Introduction: Chronic kidney disease (CKD) patients' are at risk of low vitamin D and chronic inflammation. We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum; interleukin-6 (IL-6), interleukin-10 (IL-10) and highly sensitive C-reactive protein (hs-CRP). Material and methods: A prospective randomized study in CKD stages 2-4 with serum 25-hydroxyvitamin D (25-OHD) levels < 30 ng/ml. Patients were randomized into the Vitamin D + Calcium (Vitamin D+C) or Calcium group. Serums were analyzed at baseline, week 6 and 12. Results: Fifty patients, median age of 53 (13.5) years were recruited. Their median IL-10 was 13.35 (25.22) pg/ml. At week 12, serum IL-6 was reduced in both groups (p = 0.001), serum IL-10 was maintained in the Vitamin D + C group (p = 0.06) and was reduced in the Calcium group (p = 0.001). CKD-diabetic patients had reduced serum IL-6 in both study groups (p = 0.001) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts (p = 0.005). Serum IL-10 was reduced in the Calcium group (p < 0.05) whereas serum 25-OHD rose in both groups, regardless of their diabetic status (p < 0.05). Conclusions: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics.

AB - Introduction: Chronic kidney disease (CKD) patients' are at risk of low vitamin D and chronic inflammation. We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum; interleukin-6 (IL-6), interleukin-10 (IL-10) and highly sensitive C-reactive protein (hs-CRP). Material and methods: A prospective randomized study in CKD stages 2-4 with serum 25-hydroxyvitamin D (25-OHD) levels < 30 ng/ml. Patients were randomized into the Vitamin D + Calcium (Vitamin D+C) or Calcium group. Serums were analyzed at baseline, week 6 and 12. Results: Fifty patients, median age of 53 (13.5) years were recruited. Their median IL-10 was 13.35 (25.22) pg/ml. At week 12, serum IL-6 was reduced in both groups (p = 0.001), serum IL-10 was maintained in the Vitamin D + C group (p = 0.06) and was reduced in the Calcium group (p = 0.001). CKD-diabetic patients had reduced serum IL-6 in both study groups (p = 0.001) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts (p = 0.005). Serum IL-10 was reduced in the Calcium group (p < 0.05) whereas serum 25-OHD rose in both groups, regardless of their diabetic status (p < 0.05). Conclusions: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics.

KW - Calcitriol

KW - Chronic kidney disease

KW - Diabetes

KW - Inflammation

KW - Vitamin D

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U2 - 10.5114/ceji.2014.43729

DO - 10.5114/ceji.2014.43729

M3 - Article

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VL - 39

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EP - 242

JO - Central-European Journal of Immunology

JF - Central-European Journal of Immunology

SN - 1426-3912

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