The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms During Menopausal Transition: Thermoregulatory Mechanism

Haryati Ahmad Hairi, Ahmad Nazrun Shuid, Nurul Izzah Ibrahim, Jamia Azdina Jamal, Norazlina Mohamed, Isa Naina Mohamed

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Phytoestrogens have recently been claimed to positively influence menopausal discomforts, including hot flashes. However, little is known about the influence of phytoestrogens on core body temperature during oestrogen fluctuation at menopause. OBJECTIVE: Previously published findings showed that phytoestrogens could relieve menopausal complaints, thus, the present review was aimed at assessing the effects of phytoestrogens on thermoregulatory mechanism during menopausal transition. RESULTS: The molecular mechanisms underlying hot flashes are complex. Oestrogen fluctuations cause hypothalamic thermoregulatory centre dysfunction, which leads to hot flashes during menopause. The phytoestrogens of interest, in relation to human health, include isoflavones, lignans, coumestans, and stilbenes, which are widely distributed in nature. The phytoestrogens are capable of reducing hot flashes via their oestrogen-like hormone actions. The potential effects of phytoestrogens on hot flashes and their molecular mechanisms of action on thermoregulatory centre are discussed in this review. CONCLUSION: The effects of phytoestrogens on these mechanisms may help explain their beneficial effects in alleviating hot flashes and other menopausal discomforts.

Original languageEnglish
Pages (from-to)192-200
Number of pages9
JournalCurrent Drug Targets
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Phytoestrogens
Hot Flashes
Estrogens
Menopause
Stilbenes
Lignans
Isoflavones
Body Temperature
Health
Hormones

Keywords

  • hot flashes
  • molecular
  • perimenopause
  • Phytoestrogen
  • thermoregulatory mechanism
  • vasomotor symptoms.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms During Menopausal Transition : Thermoregulatory Mechanism. / Hairi, Haryati Ahmad; Shuid, Ahmad Nazrun; Ibrahim, Nurul Izzah; Jamal, Jamia Azdina; Mohamed, Norazlina; Naina Mohamed, Isa.

In: Current Drug Targets, Vol. 20, No. 2, 01.01.2019, p. 192-200.

Research output: Contribution to journalArticle

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