The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: A randomized, double-blind, placebo-controlled study

Suzana Shahar, Ainor Farahin Aziz, Siti Nur Arina Ismail, Hanis Mastura Yahya, Normah Che Din, Zahara Abdul Manaf, Manal M. Badrasawi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Polygonum minus (PM) or locally known in Malaysia, as “kesum” is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia. Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6. Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms. Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

Original languageEnglish
Pages (from-to)1505-1520
Number of pages16
JournalClinical Interventions in Aging
Volume10
DOIs
Publication statusPublished - 22 Sep 2015

Fingerprint

Polygonum
Placebos
Wechsler Scales
Malaysia
Intelligence
Cognition
Biomarkers
Neuropsychological Tests
Micronutrients
Health Surveys
Short-Term Memory
Oxidative Stress
Antioxidants
Quality of Life
Liver

Keywords

  • Cognitive function
  • P. minus
  • Phytochemicals
  • Psychosocial
  • Quality of life
  • Women

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{f7e2ca504e234fb0b20e86eb86e24f47,
title = "The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: A randomized, double-blind, placebo-controlled study",
abstract = "Background: Polygonum minus (PM) or locally known in Malaysia, as “kesum” is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia. Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6. Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms. Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.",
keywords = "Cognitive function, P. minus, Phytochemicals, Psychosocial, Quality of life, Women",
author = "Suzana Shahar and Aziz, {Ainor Farahin} and Ismail, {Siti Nur Arina} and Yahya, {Hanis Mastura} and {Che Din}, Normah and {Abdul Manaf}, Zahara and Badrasawi, {Manal M.}",
year = "2015",
month = "9",
day = "22",
doi = "10.2147/CIA.S86411",
language = "English",
volume = "10",
pages = "1505--1520",
journal = "Clinical Interventions in Aging",
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T1 - The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women

T2 - A randomized, double-blind, placebo-controlled study

AU - Shahar, Suzana

AU - Aziz, Ainor Farahin

AU - Ismail, Siti Nur Arina

AU - Yahya, Hanis Mastura

AU - Che Din, Normah

AU - Abdul Manaf, Zahara

AU - Badrasawi, Manal M.

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Background: Polygonum minus (PM) or locally known in Malaysia, as “kesum” is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia. Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6. Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms. Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

AB - Background: Polygonum minus (PM) or locally known in Malaysia, as “kesum” is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia. Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6. Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms. Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ.

KW - Cognitive function

KW - P. minus

KW - Phytochemicals

KW - Psychosocial

KW - Quality of life

KW - Women

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