The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia

W. S S Chee, A. R. Suriah, S. P. Chan, Y. Zaitun, Y. M. Chan

    Research output: Contribution to journalArticle

    100 Citations (Scopus)

    Abstract

    Dietary studies often report low calcium intake amongst post-menopausal Malaysian women and calcium deficiency has been implicated as part of the etiology of age-related bone loss leading to osteoporosis. Therefore, the objective of this study was to examine the effectiveness of high calcium skimmed milk (Anlene Gold™, New Zealand Milk, Wellington, New Zealand) to reduce bone loss in Chinese postmenopausal women. Two hundred subjects aged 55-65 years and who were more than 5 years postmenopausal were randomized to a milk group and control group. The milk group consumed 50 g of high calcium skimmed milk powder daily, which contained 1200 mg calcium (taken as two glasses of milk a day). The control group continued with their usual diet. Using repeated measures ANCOVA, the milk supplement was found to significantly reduce the percentage of bone loss at the total body compared to the control group at 24 months (control -1.04%, milk -0.13%; P < 0.001). At the lumbar spine, the percentage of bone loss in the control group was significantly higher (-0.90%) when compared to the milk (-0.13%) supplemented group at 24 months (P < 0.05). Similarly, milk supplementation reduced the percentage of bone loss at the femoral neck (control -1.21%, milk 0.51%) (P < 0.01) and total hip (control -2.17%, milk -0.50%) (P < 0.01). The supplemented group did not experience any significant weight gain over the 24 months. The serum 25-hydroxy vitamin D level improved significantly (P < 0.01) from 69.1 ± 16.1 nmol/l at baseline to 86.4 ± 22.0 nmol/l at 24 months in the milk group. In conclusion, ingestion of high calcium skimmed milk was effective in reducing the rate of bone loss at clinically important lumbar spine and hip sites in postmenopausal Chinese women in Malaysia. Supplementing with milk had additional benefits of improving the serum 25-hydroxy vitamin D status of the subjects.

    Original languageEnglish
    Pages (from-to)828-834
    Number of pages7
    JournalOsteoporosis International
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - Oct 2003

    Fingerprint

    Malaysia
    Bone Density
    Milk
    Calcium Carbonate
    Bone and Bones
    Control Groups
    Calcium
    New Zealand
    Vitamin D
    Osteoporosis
    Hip
    Spine
    Femur Neck
    Serum
    Gold
    Powders
    Weight Gain
    Glass
    Eating
    Diet

    Keywords

    • Bone mineral density
    • Calcium
    • Milk supplementation
    • Parathyroid hormone
    • Postmenopausal Malaysian women
    • Serum 25-hydroxy vitamin D

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia. / Chee, W. S S; Suriah, A. R.; Chan, S. P.; Zaitun, Y.; Chan, Y. M.

    In: Osteoporosis International, Vol. 14, No. 10, 10.2003, p. 828-834.

    Research output: Contribution to journalArticle

    Chee, W. S S ; Suriah, A. R. ; Chan, S. P. ; Zaitun, Y. ; Chan, Y. M. / The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia. In: Osteoporosis International. 2003 ; Vol. 14, No. 10. pp. 828-834.
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    abstract = "Dietary studies often report low calcium intake amongst post-menopausal Malaysian women and calcium deficiency has been implicated as part of the etiology of age-related bone loss leading to osteoporosis. Therefore, the objective of this study was to examine the effectiveness of high calcium skimmed milk (Anlene Gold™, New Zealand Milk, Wellington, New Zealand) to reduce bone loss in Chinese postmenopausal women. Two hundred subjects aged 55-65 years and who were more than 5 years postmenopausal were randomized to a milk group and control group. The milk group consumed 50 g of high calcium skimmed milk powder daily, which contained 1200 mg calcium (taken as two glasses of milk a day). The control group continued with their usual diet. Using repeated measures ANCOVA, the milk supplement was found to significantly reduce the percentage of bone loss at the total body compared to the control group at 24 months (control -1.04{\%}, milk -0.13{\%}; P < 0.001). At the lumbar spine, the percentage of bone loss in the control group was significantly higher (-0.90{\%}) when compared to the milk (-0.13{\%}) supplemented group at 24 months (P < 0.05). Similarly, milk supplementation reduced the percentage of bone loss at the femoral neck (control -1.21{\%}, milk 0.51{\%}) (P < 0.01) and total hip (control -2.17{\%}, milk -0.50{\%}) (P < 0.01). The supplemented group did not experience any significant weight gain over the 24 months. The serum 25-hydroxy vitamin D level improved significantly (P < 0.01) from 69.1 ± 16.1 nmol/l at baseline to 86.4 ± 22.0 nmol/l at 24 months in the milk group. In conclusion, ingestion of high calcium skimmed milk was effective in reducing the rate of bone loss at clinically important lumbar spine and hip sites in postmenopausal Chinese women in Malaysia. Supplementing with milk had additional benefits of improving the serum 25-hydroxy vitamin D status of the subjects.",
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