The effect of curcumin on anxiety and recognition memory in kainate model of epileptic rats

H. Y. Yow, N. Ahmad, Norazrina Azmi, Mohd Makmor Bakry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of curcumin had been studied on anxiety and recognition memory in kainic acid-induced epilepsy. A single dose of intraperitoneal kainic acid (10 mg/kg) was used to induce status epilepticus in female Wistar rats, followed by respective treatments (vehicle dimethyl sulfoxide 50%, curcumin 100 mg/kg/d or levetiracetam 100 mg/kg/d) on the next day for 7 d, with minimum of six rats per group. The behavioural tests were performed before seizure induction and after treatment. Vehicle-treated epileptic rats showed an increase in anxiety-like behaviours in the open field test, which less observed in the light/dark box test. Levetiracetam-treated epileptic rats exhibited anxiolytic behaviours in both the tests. Curcumin-treated epileptic rats exhibited not much difference in anxiety-like behaviour before and after the treatment in open field test, but exhibited anxiolytic behaviours in light/dark box test. Kainic acid impaired the both spatial and non-spatial recognition memories of the rats. Curcumin treatment showed reversal in the non-spatial recognition impaired by kainic acid. In conclusion, kainic acid increases anxiety-like behaviours and impaired recognition memories during the early phase of epileptogenesis and curcumin was potentially improved anxiety and non-spatial recognition memory impaired by kainic acid. These benefits highlighted the potential effect of curcumin to improve psychiatric disorders in epilepsy.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalIndian Journal of Pharmaceutical Sciences
Volume79
Issue number2
Publication statusPublished - 1 Mar 2017

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Curcumin
Kainic Acid
etiracetam
Anxiety
Anti-Anxiety Agents
Epilepsy
Light
Status Epilepticus
Dimethyl Sulfoxide
Psychiatry
Recognition (Psychology)
Wistar Rats
Seizures

Keywords

  • Anxiety
  • Cognitive function
  • Epileptogenesis
  • Kainic acid
  • Novel object recognition
  • Recognition memory

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

The effect of curcumin on anxiety and recognition memory in kainate model of epileptic rats. / Yow, H. Y.; Ahmad, N.; Azmi, Norazrina; Makmor Bakry, Mohd.

In: Indian Journal of Pharmaceutical Sciences, Vol. 79, No. 2, 01.03.2017, p. 267-276.

Research output: Contribution to journalArticle

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