Kesan Penuaan ke atas Kehubungan Berkesan Otak semasa Pemprosesan Ingatan Bekerja daripada Perspektif Pemodelan Sebab dan Akibat Dinamik

Translated title of the contribution: The effect of ageing on brain effective connectivity during working memory processing from the perspective of dynamic causal modelling

Hanani Abdul Manan, Ahmad Nazlim Yusoff, Siti Zamratol Mai Sarah Mukari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ageing process is often associated with cognitive system declination. The decline begins as early as in the twenties and continues linearly. However, the effects of ageing on connectivity charactersistics between the brain areas have yet to be understood. In the present study, functional magnetic resonance imaging (fMRI) was used to investigate the effects of ageing on brain connectivity resulting from the backward repeat task (BRT). Normal participants with four age groups which were 20-29 years (n=14), 30-39 years (n=14), 40-49 years (n=10) and 50-65 years (n=14) participated in this study. The BRT stimulus consisted of a series of five words given auditorily. Statistical parametric mapping (SPM) and dynamic causal modeling (DCM) was used to determine brain activation and connectivity. Two-hundred intrahemispheric and 150 interhemispheric connectivity models were constructed to test the existence of coupling between superior temporal gyrus (STG), Heschl's gyrus (HG), thalamus (TH) and precentral gyrus (PCG) on all subjects. DCM results showed that participants from the four age groups used the same intrahemispheric connectivity during BRT task. The interhemipheric connectivity changed and became more complex with ageing. The change was found to start at the age of 40. This result supports previous finding that ageing causes changes in the brain neuronal system and consequently affects cognitive processing.

Original languageMalay
Pages (from-to)1339-1350
Number of pages12
JournalSains Malaysiana
Volume44
Issue number9
Publication statusPublished - 1 Sep 2015

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Short-Term Memory
Brain
Age Groups
Auditory Cortex
Frontal Lobe
Temporal Lobe
Thalamus
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • General

Cite this

Kesan Penuaan ke atas Kehubungan Berkesan Otak semasa Pemprosesan Ingatan Bekerja daripada Perspektif Pemodelan Sebab dan Akibat Dinamik. / Manan, Hanani Abdul; Yusoff, Ahmad Nazlim; Mukari, Siti Zamratol Mai Sarah.

In: Sains Malaysiana, Vol. 44, No. 9, 01.09.2015, p. 1339-1350.

Research output: Contribution to journalArticle

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