The biological activities of oleocanthal from a molecular perspective

Kok Lun Pang, Chin Kok Yong

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since the pathogenesis of many chronic diseases involves inflammatory and oxidative components, oleocanthal is a promising agent to prevent these conditions. This review aimed to summarise the current beneficial health effects of oleocanthal and the molecular basis of its biological actions. The anti-inflammatory, antioxidative, antimicrobial, anticancer and neuroprotective activities of oleocanthal have been examined by previous studies. Of these, studies on the anticancer effects have been the most extensive. Oleocanthal was reported to suppress melanoma, breast, liver, and colon cancer cells. Neurological studies focused on the effects of oleocanthal against Alzheimer’s disease. Oleocanthal improved clearance of the amyloid beta protein from neurons and reduced the inflammation of astrocytes. Despite the positive results, validation of the biological effects of oleocanthal in animal disease models is limited and should be emphasized in the future. As a conclusion, oleocanthal may act together with other bioactive compounds in olive oil to achieve its therapeutic potential. The use of oleocanthal alone as a single therapeutic measure awaits validation from future studies.

Original languageEnglish
Article number570
JournalNutrients
Volume10
Issue number5
DOIs
Publication statusPublished - 1 May 2018

Fingerprint

bioactive properties
olive oil
Anti-Inflammatory Agents
animal disease models
oleocanthal
Animal Disease Models
neuroprotective effect
therapeutics
liver neoplasms
Amyloid beta-Peptides
astrocytes
amyloid
Alzheimer disease
Liver Neoplasms
melanoma
anti-inflammatory activity
colorectal neoplasms
chronic diseases
Astrocytes
breast neoplasms

Keywords

  • Alzheimer’s disease
  • Antioxidant
  • Cancer
  • Inflammation
  • Neuroprotection
  • Oleocanthal
  • Olive

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The biological activities of oleocanthal from a molecular perspective. / Pang, Kok Lun; Kok Yong, Chin.

In: Nutrients, Vol. 10, No. 5, 570, 01.05.2018.

Research output: Contribution to journalReview article

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