The association of the HLA class II antigens with clinical and autoantibody expression in Malaysian Chinese patients with systemic lupus erythematosus

M. R. Azizah, S. S. Ainol, S. H. Kuak, N. C T Kong, Y. Normaznah, M. N. Rahim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The frequency of the HLA class II antigens/alleles (HLA-DR, DQ and DP) were studied in 70 Malaysian Chinese patients with systemic lupus erythematosus (SLE) to examine the contribution of these genes to disease susceptibility, their clinical expression and immunological responses. This was done using modified PCR-RFLP technique. These samples were than compared with 66 ethnically matched controls. We found a strong association of the DQA1*0102 (p corr = 0.032, rr = 3.39), DQB1*0501 (p corr = 0.003, rr = 4.55), *0601 (p corr = 0.006, rr = 4.22) and DPB1*0901 (p corr = 0.02, rr = 4.58) with SLE. Clinically, we found a strong association of DR2 and DQA1*0301 with renal involvement and DQA1*0102 with alopecia. Immunologically, statistical analysis (Chi-square test) showed a strong association of DQA1*0102 with anti-Ro/La antibodies while DQA1*0301 was observed to be strongly associated with antibodies to ds DNA. DQA1*0102 was found more frequently in those with a later disease onset (30 years of age or above). From these data we suggest that the HLA class II genes play a role in conferring disease susceptibility and clinical and immunological expression.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalAsian Pacific Journal of Allergy and Immunology
Volume19
Issue number2
Publication statusPublished - 2001
Externally publishedYes

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Histocompatibility Antigens Class II
Disease Susceptibility
HLA Antigens
Systemic Lupus Erythematosus
Autoantibodies
HLA-DP Antigens
HLA-DQ Antigens
MHC Class II Genes
Alopecia
HLA-DR Antigens
Chi-Square Distribution
Restriction Fragment Length Polymorphisms
Alleles
Kidney
Polymerase Chain Reaction
Antibodies
DNA
Genes
SS-A antibodies
Late Onset Disorders

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

The association of the HLA class II antigens with clinical and autoantibody expression in Malaysian Chinese patients with systemic lupus erythematosus. / Azizah, M. R.; Ainol, S. S.; Kuak, S. H.; Kong, N. C T; Normaznah, Y.; Rahim, M. N.

In: Asian Pacific Journal of Allergy and Immunology, Vol. 19, No. 2, 2001, p. 93-100.

Research output: Contribution to journalArticle

Azizah, M. R. ; Ainol, S. S. ; Kuak, S. H. ; Kong, N. C T ; Normaznah, Y. ; Rahim, M. N. / The association of the HLA class II antigens with clinical and autoantibody expression in Malaysian Chinese patients with systemic lupus erythematosus. In: Asian Pacific Journal of Allergy and Immunology. 2001 ; Vol. 19, No. 2. pp. 93-100.
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