The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia

Zariyantey Abd Hamid, Mohd Faizal Mohd Zulkifly, Asmah Hamid, Syarif Husin Lubis, Nihayah Mohammad, Ismarulyusda Ishak, Nur Zakiah Mohd Saat, Hidayatul Fathi Othman, Ahmad Rohi Ghazali, Mohd Jamil Mohd Rafaai, Mohamad Roff Mohd Noor, Nor Fadilah Rajab

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Abstract

Background: Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxicity in occupationally exposed farmers in Malaysia remain underreported. Thus, this study was aimed to determine the presence of nuclear abnormalities through the assessment of micronucleus (MN) and binucleus (BNu) frequencies in exfoliated buccal epithelial cells from farmers who were exposed to pesticides. A crosssectional study of farmers among different agricultural activities farmers in Bachok and Pasir Puteh, Kelantan, North East of Peninsular Malaysia was done to evaluate the presence of nuclear abnormalities and its correlation with their health status and farming activities. Results: Analysis of buccal cells revealed that the frequency of MN was significantly higher (p <0.05) in farmers as compared to controls. In contrast, no significant difference (p > 0.05) was observed for BNu frequency in between groups. Correlation analysis showed that apart from a significant (p <0.05) and positive correlation between the duration of fertilizers exposure and frequencies of MN (r = 0.42, P = 0.001) and BNu (r = 0.37, P = 0.02), no other correlation of various confounding factors on the formation of MN and BNu were observed. Conclusion: In conclusion, pesticide and fertilizers exposure may contribute to the promotion of nuclear anomalies among Malaysian farmers who are engaged in mixed plantation activities. Further assessment of larger populations is important to address and overcome the potential risk of pesticide-induced genotoxicity.

Original languageEnglish
Article number7
JournalGenes and Environment
Volume38
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Cheek
Malaysia
health status
abnormality
Pesticides
Health Status
pesticide
Epithelial Cells
genotoxicity
Fertilizers
fertilizer
Agriculture
Farmers
Epidemiologic Studies
plantation
toxicity
anomaly
Population
exposure

Keywords

  • Binucleus
  • Buccal cells
  • Farmers
  • Micronucleus
  • Pesticides

ASJC Scopus subject areas

  • Genetics
  • Environmental Science (miscellaneous)
  • Social Psychology

Cite this

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title = "The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia",
abstract = "Background: Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxicity in occupationally exposed farmers in Malaysia remain underreported. Thus, this study was aimed to determine the presence of nuclear abnormalities through the assessment of micronucleus (MN) and binucleus (BNu) frequencies in exfoliated buccal epithelial cells from farmers who were exposed to pesticides. A crosssectional study of farmers among different agricultural activities farmers in Bachok and Pasir Puteh, Kelantan, North East of Peninsular Malaysia was done to evaluate the presence of nuclear abnormalities and its correlation with their health status and farming activities. Results: Analysis of buccal cells revealed that the frequency of MN was significantly higher (p <0.05) in farmers as compared to controls. In contrast, no significant difference (p > 0.05) was observed for BNu frequency in between groups. Correlation analysis showed that apart from a significant (p <0.05) and positive correlation between the duration of fertilizers exposure and frequencies of MN (r = 0.42, P = 0.001) and BNu (r = 0.37, P = 0.02), no other correlation of various confounding factors on the formation of MN and BNu were observed. Conclusion: In conclusion, pesticide and fertilizers exposure may contribute to the promotion of nuclear anomalies among Malaysian farmers who are engaged in mixed plantation activities. Further assessment of larger populations is important to address and overcome the potential risk of pesticide-induced genotoxicity.",
keywords = "Binucleus, Buccal cells, Farmers, Micronucleus, Pesticides",
author = "{Abd Hamid}, Zariyantey and Zulkifly, {Mohd Faizal Mohd} and Asmah Hamid and Lubis, {Syarif Husin} and Nihayah Mohammad and Ismarulyusda Ishak and {Mohd Saat}, {Nur Zakiah} and Othman, {Hidayatul Fathi} and Ghazali, {Ahmad Rohi} and Rafaai, {Mohd Jamil Mohd} and Noor, {Mohamad Roff Mohd} and Rajab, {Nor Fadilah}",
year = "2016",
doi = "10.1186/s41021-016-0032-1",
language = "English",
volume = "38",
journal = "Genes and Environment",
issn = "1880-7046",
publisher = "The Japanese Environmental Mutagen Society",
number = "1",

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TY - JOUR

T1 - The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia

AU - Abd Hamid, Zariyantey

AU - Zulkifly, Mohd Faizal Mohd

AU - Hamid, Asmah

AU - Lubis, Syarif Husin

AU - Mohammad, Nihayah

AU - Ishak, Ismarulyusda

AU - Mohd Saat, Nur Zakiah

AU - Othman, Hidayatul Fathi

AU - Ghazali, Ahmad Rohi

AU - Rafaai, Mohd Jamil Mohd

AU - Noor, Mohamad Roff Mohd

AU - Rajab, Nor Fadilah

PY - 2016

Y1 - 2016

N2 - Background: Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxicity in occupationally exposed farmers in Malaysia remain underreported. Thus, this study was aimed to determine the presence of nuclear abnormalities through the assessment of micronucleus (MN) and binucleus (BNu) frequencies in exfoliated buccal epithelial cells from farmers who were exposed to pesticides. A crosssectional study of farmers among different agricultural activities farmers in Bachok and Pasir Puteh, Kelantan, North East of Peninsular Malaysia was done to evaluate the presence of nuclear abnormalities and its correlation with their health status and farming activities. Results: Analysis of buccal cells revealed that the frequency of MN was significantly higher (p <0.05) in farmers as compared to controls. In contrast, no significant difference (p > 0.05) was observed for BNu frequency in between groups. Correlation analysis showed that apart from a significant (p <0.05) and positive correlation between the duration of fertilizers exposure and frequencies of MN (r = 0.42, P = 0.001) and BNu (r = 0.37, P = 0.02), no other correlation of various confounding factors on the formation of MN and BNu were observed. Conclusion: In conclusion, pesticide and fertilizers exposure may contribute to the promotion of nuclear anomalies among Malaysian farmers who are engaged in mixed plantation activities. Further assessment of larger populations is important to address and overcome the potential risk of pesticide-induced genotoxicity.

AB - Background: Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxicity in occupationally exposed farmers in Malaysia remain underreported. Thus, this study was aimed to determine the presence of nuclear abnormalities through the assessment of micronucleus (MN) and binucleus (BNu) frequencies in exfoliated buccal epithelial cells from farmers who were exposed to pesticides. A crosssectional study of farmers among different agricultural activities farmers in Bachok and Pasir Puteh, Kelantan, North East of Peninsular Malaysia was done to evaluate the presence of nuclear abnormalities and its correlation with their health status and farming activities. Results: Analysis of buccal cells revealed that the frequency of MN was significantly higher (p <0.05) in farmers as compared to controls. In contrast, no significant difference (p > 0.05) was observed for BNu frequency in between groups. Correlation analysis showed that apart from a significant (p <0.05) and positive correlation between the duration of fertilizers exposure and frequencies of MN (r = 0.42, P = 0.001) and BNu (r = 0.37, P = 0.02), no other correlation of various confounding factors on the formation of MN and BNu were observed. Conclusion: In conclusion, pesticide and fertilizers exposure may contribute to the promotion of nuclear anomalies among Malaysian farmers who are engaged in mixed plantation activities. Further assessment of larger populations is important to address and overcome the potential risk of pesticide-induced genotoxicity.

KW - Binucleus

KW - Buccal cells

KW - Farmers

KW - Micronucleus

KW - Pesticides

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U2 - 10.1186/s41021-016-0032-1

DO - 10.1186/s41021-016-0032-1

M3 - Article

C2 - 26872746

AN - SCOPUS:84973520061

VL - 38

JO - Genes and Environment

JF - Genes and Environment

SN - 1880-7046

IS - 1

M1 - 7

ER -