The antioxidant effect of derivatives pyroglutamic lactam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diphenylpicrylhydrazyl (DPPH) is widely used for quickly accessing the ability of polyphenols to transfer labile H atoms to radicals. The antioxidant activity of all the synthesized compounds was screened by DPPH method. Compound (4) showed 54% antioxidant potential while all other compounds were found to have moderate to have moderate to mild antioxidant activity ranging from 47-52%. Pyroglutamic lactams have been synthesized stereoselectively in racemic form from levulinic acid as bifunctional adduct using convertible isocyanide in one-pot Ugi 4-center-3-component condensation reaction (U-4C-3CR). The product formed provides biologically interesting products in excellent yields in a short reaction time. The structures of the synthesized compounds were elucidated using spectroscopic data and elemental analysis.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages801-805
Number of pages5
Volume1571
DOIs
Publication statusPublished - 2013
Event2013 UKM Faculty of Science and Technology Post-Graduate Colloquium - Selangor
Duration: 3 Jul 20134 Jul 2013

Other

Other2013 UKM Faculty of Science and Technology Post-Graduate Colloquium
CitySelangor
Period3/7/134/7/13

Fingerprint

antioxidants
products
reaction time
adducts
condensation
acids
atoms

Keywords

  • Antioxidant
  • Pyroglutamic lactam

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

The antioxidant effect of derivatives pyroglutamic lactam. / Rohadi, Atisya; Mat Lazim, Mohamad Azwani Shah; Hasbullah, Siti Aishah.

AIP Conference Proceedings. Vol. 1571 2013. p. 801-805.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rohadi, A, Mat Lazim, MAS & Hasbullah, SA 2013, The antioxidant effect of derivatives pyroglutamic lactam. in AIP Conference Proceedings. vol. 1571, pp. 801-805, 2013 UKM Faculty of Science and Technology Post-Graduate Colloquium, Selangor, 3/7/13. https://doi.org/10.1063/1.4858753
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