The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model

Ahmad Nazrun Shuid, Mohd Firdaus Abu Bakar, Tajul Ariff Abdul Shukor, Norliza Muhammad, Norazlina Mohamed, Ima Nirwana Soelaiman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Osteoporosis in elderly men is becoming an important health issue with the aging society. Elderly men with androgen deficiency are exposed to osteoporosis and can be treated with testosterone replacement. In this study, Eurycoma longifolia (EL), a plant with androgenic effects, was supplemented to an androgen-deficient osteoporotic aged rat as alternative to testosterone. Aged 12 months old Sprague-Dawley rats were divided into groups of normal control (NC), sham-operated (SO), orchidectomised-control (OrxC), orchidectomised and supplemented with EL (Orx + El) and orchidectomised and given testosterone (Orx + T). After 6 weeks of treatment, serum osteocalcin, serum terminal C-telopeptide Type 1 collagen (CTX) and the fourth lumbar bone calcium were measured. There were no significant differences in the osteocalcin levels before and after treatment in all the groups. The CTX levels were also similar for all the groups before treatment. However, after treatment, orchidectomy had caused significant elevation of CTX compared to normal control rats. Testosterone replacements in orchidectomised rats were able to prevent the rise of CTX. Orchidectomy had also reduced the bone calcium level compared to normal control rats. Both testosterone replacement and EL supplementation to orchidectomised rats were able to maintain the bone calcium level, with the former showing better effects. As a conclusion, EL prevented bone calcium loss in orchidectomised rats and therefore has the potential to be used as an alternative treatment for androgen deficient osteoporosis.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalAging Male
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Eurycoma
Testosterone
Androgens
Osteoporosis
Calcium
Bone and Bones
Orchiectomy
Osteocalcin
Therapeutics
Collagen Type I
Serum
Sprague Dawley Rats
Control Groups
Health

Keywords

  • bone calcium
  • Eurycoma longifolia
  • osteoporosis
  • testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model. / Shuid, Ahmad Nazrun; Abu Bakar, Mohd Firdaus; Abdul Shukor, Tajul Ariff; Muhammad, Norliza; Mohamed, Norazlina; Soelaiman, Ima Nirwana.

In: Aging Male, Vol. 14, No. 3, 09.2011, p. 150-154.

Research output: Contribution to journalArticle

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