The anti-inflammatory properties of Au-scopoletin nanoconjugates

Muhammad Raza Shah, Anwar Shamim, Lauren S. White, Massimo F. Bertino, Osman Mesaik Mohammed Ahmed Hassan, Samreen Soomro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We investigated the biological activity of Au nanoparticles with a mean diameter of 30 nm which were capped with scopoletin, a natural coumarin isolated from Artemisia roxburghiana along with eleven other natural products. The NO inhibitory activity of scopoletin was unaffected by conjugation to the Au nanoparticles. A luminol chemiluminescence assay showed instead that conjugation increased the prevention of an oxidative burst of reactive oxygen species (ROS) in whole blood phagocytes and isolated neutrophils (PMN) by about three times. This journal is

Original languageEnglish
Pages (from-to)5566-5572
Number of pages7
JournalNew Journal of Chemistry
Volume38
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014

Fingerprint

Nanoconjugates
Scopoletin
Anti-Inflammatory Agents
Nanoparticles
Luminol
Chemiluminescence
Bioactivity
Biological Products
Assays
Reactive Oxygen Species
Blood
Oxygen

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Materials Chemistry

Cite this

Shah, M. R., Shamim, A., White, L. S., Bertino, M. F., Mohammed Ahmed Hassan, O. M., & Soomro, S. (2014). The anti-inflammatory properties of Au-scopoletin nanoconjugates. New Journal of Chemistry, 38(11), 5566-5572. https://doi.org/10.1039/c4nj00792a

The anti-inflammatory properties of Au-scopoletin nanoconjugates. / Shah, Muhammad Raza; Shamim, Anwar; White, Lauren S.; Bertino, Massimo F.; Mohammed Ahmed Hassan, Osman Mesaik; Soomro, Samreen.

In: New Journal of Chemistry, Vol. 38, No. 11, 01.11.2014, p. 5566-5572.

Research output: Contribution to journalArticle

Shah, MR, Shamim, A, White, LS, Bertino, MF, Mohammed Ahmed Hassan, OM & Soomro, S 2014, 'The anti-inflammatory properties of Au-scopoletin nanoconjugates', New Journal of Chemistry, vol. 38, no. 11, pp. 5566-5572. https://doi.org/10.1039/c4nj00792a
Shah MR, Shamim A, White LS, Bertino MF, Mohammed Ahmed Hassan OM, Soomro S. The anti-inflammatory properties of Au-scopoletin nanoconjugates. New Journal of Chemistry. 2014 Nov 1;38(11):5566-5572. https://doi.org/10.1039/c4nj00792a
Shah, Muhammad Raza ; Shamim, Anwar ; White, Lauren S. ; Bertino, Massimo F. ; Mohammed Ahmed Hassan, Osman Mesaik ; Soomro, Samreen. / The anti-inflammatory properties of Au-scopoletin nanoconjugates. In: New Journal of Chemistry. 2014 ; Vol. 38, No. 11. pp. 5566-5572.
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