The A-B-C of haematopoietic stem cell transplantation.

Research output: Contribution to journalArticle

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Abstract

Haematopoietic stem cell transplantation (HSCT) has progressed rapidly since its introduction about five decades ago. There is now an increasing demand for transplant physicians in both public and private domains to perform this procedure in view of significant improvement of remission rates in haematological malignancies and increasing indications of HSCT. Peripheral blood has largely replaced bone marrow as the preferred source of haematopoietic stem cells (HSC). Transplantation-related mortality and morbidity rates have considerably decreased because of improved conditioning regimens, human leukocyte antigen (HLA) typing methods, supportive care, and most importantly, prophylaxis, diagnosis and treatment of serious infections. New transplantation strategies, such as reduced intensity transplantation, have extended the use of allogeneic transplant to patients with older age and co-morbidities. Current efforts are focused on ways to increase the donor pool and to improve the long term outcome of HSCT survivors in particular to reduce the relapse rate and the late effects of HSCT. This article summarizes the sources and procurement of HSC, the types and process of HSCT, indications for HSCT and complications associated with HSCT with particular reference to the current practice within the local settings.

Original languageEnglish
JournalThe Medical journal of Malaysia
Volume64
Issue number1
Publication statusPublished - Mar 2009

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Hematopoietic Stem Cell Transplantation
Transplantation
Hematopoietic Stem Cells
Morbidity
Transplants
Public Sector
Hematologic Neoplasms
HLA Antigens
Survivors
Bone Marrow
Tissue Donors
Physicians
Recurrence
Mortality
Infection

ASJC Scopus subject areas

  • Medicine(all)

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The A-B-C of haematopoietic stem cell transplantation. / Tumian, Nor Rafeah; S. Abdul Wahid, S Fadilah.

In: The Medical journal of Malaysia, Vol. 64, No. 1, 03.2009.

Research output: Contribution to journalArticle

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