Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics

W. M. Wan Nazaimoon, R. Letchuman, N. Noraini, A. R. Ropilah, M. Zainal, I. S. Ismail, W. B. Wan Mohamad, I. Faridah, M. Singaraveloo, I. H. Sheriff, B. A K Khalid

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This cross-sectional study looked at the prevalence of microalbuminuria and retinopathy in a cohort of 926 young, Type 1 and Type 2 diabetes mellitus (DM) patients, and determined the factors which were associated with these microvascular complications. The prevalence of microalbuminuria, defined as the albumin:creatinine ratio ≥ 2.5 (for males) or ≥ 3.5 mg/mmol (for females), was 13.4% in Type 1 DM, 69.5% in insulin-requiring Type 2 DM and 16% in Type 2 DM treated only with oral hypoglycemic agents. Compared to those with normal renal functions, these patients were older (P ≤ 0.01), had significantly elevated blood pressures (P < 0.01 or P = 0.0001), and in the case of Type 1 DM, with a higher body mass index (P = 0.0001) and waist-hip ratio (P < 0.01). The prevalence of diabetic retinopathy in Type 1 DM was found to increase with the duration of diabetes, from 1.4% in the newly-onset (< 5 years), to 9.9% in those with 5-10 years disease, to 35% among patients with more than 10 years of diabetes (P < 0.0001). In this study, it was also observed that 10% of the Type 2 DM patients already had retinopathy within 5 years of diagnosis, and the prevalence increased significantly to 42.9% (P < 0.0001) among patients who had been diabetics for more than 10 years. Stepwise multiple regression analysis showed that besides the disease duration, systolic blood pressure was the most common and significant determinant for both microalbuminuria and retinopathy in both types of DM, thus implying that in order to reduce the risk of microvascular complications in diabetes mellitus, systolic and not just the diastolic blood pressure, should be effectively controlled.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume46
Issue number3
DOIs
Publication statusPublished - Dec 1999
Externally publishedYes

Fingerprint

Diabetes Mellitus
Type 2 Diabetes Mellitus
Blood Pressure
Hypertension
Type 1 Diabetes Mellitus
Waist-Hip Ratio
Diabetic Retinopathy
Diabetes Complications
Hypoglycemic Agents
Albumins
Creatinine
Body Mass Index
Cross-Sectional Studies
Regression Analysis
Insulin
Kidney

Keywords

  • Blood pressure
  • Microalbuminuria
  • Retinopathy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics. / Wan Nazaimoon, W. M.; Letchuman, R.; Noraini, N.; Ropilah, A. R.; Zainal, M.; Ismail, I. S.; Wan Mohamad, W. B.; Faridah, I.; Singaraveloo, M.; Sheriff, I. H.; Khalid, B. A K.

In: Diabetes Research and Clinical Practice, Vol. 46, No. 3, 12.1999, p. 213-221.

Research output: Contribution to journalArticle

Wan Nazaimoon, WM, Letchuman, R, Noraini, N, Ropilah, AR, Zainal, M, Ismail, IS, Wan Mohamad, WB, Faridah, I, Singaraveloo, M, Sheriff, IH & Khalid, BAK 1999, 'Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics', Diabetes Research and Clinical Practice, vol. 46, no. 3, pp. 213-221. https://doi.org/10.1016/S0168-8227(99)00095-9
Wan Nazaimoon, W. M. ; Letchuman, R. ; Noraini, N. ; Ropilah, A. R. ; Zainal, M. ; Ismail, I. S. ; Wan Mohamad, W. B. ; Faridah, I. ; Singaraveloo, M. ; Sheriff, I. H. ; Khalid, B. A K. / Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics. In: Diabetes Research and Clinical Practice. 1999 ; Vol. 46, No. 3. pp. 213-221.
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AU - Ropilah, A. R.

AU - Zainal, M.

AU - Ismail, I. S.

AU - Wan Mohamad, W. B.

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AU - Sheriff, I. H.

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