Systemic lupus erythematosus with a non functioning pituitary macroadenoma

Ummi Nadira, Rizna Abdul Cader, Norella C T Kong, Rozita Mohd, Abdul Halim Abdul Gafor

Research output: Contribution to journalArticle

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Abstract

Background: Malignancies are more common in patients with systemic lupus erythematosus (SLE) than the general population. SLE patients are recognized to have higher prolactin levels. However, there are very few reported cases of SLE with pituitary adenomas. Case Report: We report the second case of a pituitary adenoma in a patient with underlying SLE. A 51 year old lady presented with blurred vision and magnetic resonance imaging of the brain demonstrated a pituitary macroadenoma with mildly elevated serum prolactin levels. The diagnosis of a non functioning pituitary macroadenoma was confirmed histologically. The diagnosis of SLE was made on the basis of thrombocytopenia, antinuclear antibodies, anti double stranded DNA antibodies and lupus nephritis (confirmed on renal biopsy). The patient initially received medical therapy with carbegoline, followed by transsphenoidal neurosurgery for the pituitary macroadenoma. SLE with lupus nephritis was treated with steroids and low dose intravenous cyclophosphamide. Conclusions: Hyperprolactinaemia is prevalent in twenty to thirty percent of SLE patients but it is rarely due to a prolactinoma. The source of excessive circulating prolactin in SLE patients has not been fully determined.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalAmerican Journal of Case Reports
Volume13
Publication statusPublished - 19 Jul 2012

Fingerprint

Systemic Lupus Erythematosus
Prolactin
Lupus Nephritis
Pituitary Neoplasms
Prolactinoma
Hyperprolactinemia
Antinuclear Antibodies
Neurosurgery
Thrombocytopenia
Cyclophosphamide
Steroids
Magnetic Resonance Imaging
Kidney
Biopsy
Antibodies
DNA
Brain
Serum
Population
Neoplasms

Keywords

  • Pituitary macroadenoma
  • Prolactin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Systemic lupus erythematosus with a non functioning pituitary macroadenoma. / Nadira, Ummi; Abdul Cader, Rizna; Kong, Norella C T; Mohd, Rozita; Abdul Gafor, Abdul Halim.

In: American Journal of Case Reports, Vol. 13, 19.07.2012, p. 160-162.

Research output: Contribution to journalArticle

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