Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity

Osman Mesaik Mohammed Ahmed Hassan, Khalid Mohammed Khan, Fazal Rahim, Muhammad Taha, Syed Moazzam Haider, Shahnaz Perveen, Ahmed Shukralla Khalid, Omer M. Abdalla, Samreen Soomro, Wolfgang Voelter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalBioorganic Chemistry
Volume60
DOIs
Publication statusPublished - 25 May 2015

Fingerprint

Mannich Bases
Aptitude
Cellular Immunity
Interleukin-4
Reactive Oxygen Species
Nitric Oxide
T-cells
T-Lymphocytes
Immunologic Factors
Interleukin-2
Cell Proliferation
Cell proliferation
Monitoring
In Vitro Techniques
indole

Keywords

  • Cytokine inhibition
  • Indole Mannich base
  • Nitric oxide
  • ROS

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Mohammed Ahmed Hassan, O. M., Khan, K. M., Rahim, F., Taha, M., Haider, S. M., Perveen, S., ... Voelter, W. (2015). Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity. Bioorganic Chemistry, 60, 118-122. https://doi.org/10.1016/j.bioorg.2015.05.003

Synthetic indole Mannich bases : Their ability to modulate in vitro cellular immunity. / Mohammed Ahmed Hassan, Osman Mesaik; Khan, Khalid Mohammed; Rahim, Fazal; Taha, Muhammad; Haider, Syed Moazzam; Perveen, Shahnaz; Khalid, Ahmed Shukralla; Abdalla, Omer M.; Soomro, Samreen; Voelter, Wolfgang.

In: Bioorganic Chemistry, Vol. 60, 25.05.2015, p. 118-122.

Research output: Contribution to journalArticle

Mohammed Ahmed Hassan, OM, Khan, KM, Rahim, F, Taha, M, Haider, SM, Perveen, S, Khalid, AS, Abdalla, OM, Soomro, S & Voelter, W 2015, 'Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity', Bioorganic Chemistry, vol. 60, pp. 118-122. https://doi.org/10.1016/j.bioorg.2015.05.003
Mohammed Ahmed Hassan OM, Khan KM, Rahim F, Taha M, Haider SM, Perveen S et al. Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity. Bioorganic Chemistry. 2015 May 25;60:118-122. https://doi.org/10.1016/j.bioorg.2015.05.003
Mohammed Ahmed Hassan, Osman Mesaik ; Khan, Khalid Mohammed ; Rahim, Fazal ; Taha, Muhammad ; Haider, Syed Moazzam ; Perveen, Shahnaz ; Khalid, Ahmed Shukralla ; Abdalla, Omer M. ; Soomro, Samreen ; Voelter, Wolfgang. / Synthetic indole Mannich bases : Their ability to modulate in vitro cellular immunity. In: Bioorganic Chemistry. 2015 ; Vol. 60. pp. 118-122.
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