Synthesis, structurale elucidation and antioxidant study of Ortho-substituted N,N'-bis(benzamidothiocarbonyl)hydrazine derivatives

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Abstract

Some bis(thiourea) compounds have been reported to posses excellent performance in pharmaceutical and environmental fields because of their ability to form chelating complexes with various anions and metal ions. Structurally for carbonyl thiourea derivatives, to become a chelating agent, it must adopt cis-configuration. In the present study, four new bis(thiourea) derivatives namely N,N'-bis(o-fluorobenzamidothiocarbonyl)hydrazine (1), N,N'- bis(o-chloro-benzamidothiocarbonyl)hydrazine (2), N,N'-bis(o-nitrobenzamidothiocarbonyl)-hydrazine (3), and N,N'-bis(o-methylbenzamidothiocarbonyl)hydrazine (4) were successfully synthesized and characterized by CHNS microelemental analysis, FTIR, UV-Vis, and 1H and 13C NMR spectroscopy. However chemical crystallography study showed that both thiourea moieties in compound (2) and (3) adopt trans geometry. Therefore they are potential monodentate ligand with two active moieties. DPPH radical scavenging experiment showed that compound (1), (2), and (4) exhibited higher antioxidant activity than ascorbic acid (Vitamin C).

Original languageEnglish
Article number012010
JournalJournal of Physics: Conference Series
Volume979
Issue number1
DOIs
Publication statusPublished - 13 Mar 2018
Event2nd International Conference on Science, ICOS 2017 - Makassar, Indonesia
Duration: 2 Nov 20173 Nov 2017

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thioureas
antioxidants
hydrazines
ascorbic acid
synthesis
scavenging
crystallography
metal ions
anions
nuclear magnetic resonance
ligands
geometry
configurations
spectroscopy
ions

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

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title = "Synthesis, structurale elucidation and antioxidant study of Ortho-substituted N,N'-bis(benzamidothiocarbonyl)hydrazine derivatives",
abstract = "Some bis(thiourea) compounds have been reported to posses excellent performance in pharmaceutical and environmental fields because of their ability to form chelating complexes with various anions and metal ions. Structurally for carbonyl thiourea derivatives, to become a chelating agent, it must adopt cis-configuration. In the present study, four new bis(thiourea) derivatives namely N,N'-bis(o-fluorobenzamidothiocarbonyl)hydrazine (1), N,N'- bis(o-chloro-benzamidothiocarbonyl)hydrazine (2), N,N'-bis(o-nitrobenzamidothiocarbonyl)-hydrazine (3), and N,N'-bis(o-methylbenzamidothiocarbonyl)hydrazine (4) were successfully synthesized and characterized by CHNS microelemental analysis, FTIR, UV-Vis, and 1H and 13C NMR spectroscopy. However chemical crystallography study showed that both thiourea moieties in compound (2) and (3) adopt trans geometry. Therefore they are potential monodentate ligand with two active moieties. DPPH radical scavenging experiment showed that compound (1), (2), and (4) exhibited higher antioxidant activity than ascorbic acid (Vitamin C).",
author = "Syadza Firdausiah and Hasbullah, {Siti Aishah} and {Mohd. Yamin}, Bohari",
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