Sintesis, struktur, sifat-sifat kimia, dan penyaringan antibakteria bagi kompleks Sm(III) tiosemikarbazon

Translated title of the contribution: Synthesis, structural, chemical properties, and anti-bacterial screening of Sm(III) thiosemicarbazone complexes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rare earth complexes can exhibit higher coordination numbers while rare earth metals have the ability to form a multitude of geometries with organic ligands. The ligands, [Sm(III) (4Acpy4MTSC)2(4H2O)Cl]Cl2and [Sm(III) (4Acpy4ETSC)(5H2O)Cl2]Cl [4Acpy4MTSC = 4-acetylpyridine 4-methyl-3-thiosemicarbazone; 4Acpy4ETSC = 4-acetylpyridine 4-ethyl-3-thiosemicarbazone] have been synthesised by condensation method. The compounds were structurally characterised by elemental analysis (CHNS), molar conductivity, Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Ultraviolet-Visible (UV-Vis), and Thermo-Gravimetric Analysis (TGA). The elemental analysis for the compounds were in a good agreement with the theoretical values. The molar conductivity of the complexes showed electrolyte behaviour and confirmed the presence of counter ions in the structures. The proposed structures of the compounds have been confirmed by NMR, UV-Vis, and TGA. Based on the analysis, the ligands were coordinated to the metal ions through azomethine N and thione S thus, producing bidentate complexes. From the TGA, it is confirmed that a few water molecules have coordinated with metal ions. The X-ray crystallographic structures for the 4Acpy4ETSC, the C=S bond length is shorter than the single bond C-S which is 1.82 Å. It shows that in the solid state, the ligand exists in the thione form. The 4Acpy4ETSC adopted a monoclinic system, a = 10.5922(7), b = 8.9597(6), c = 13.0407, Z = 4. In vitro antibacterial tests showed that the complexes have an effective inhibitory effect compared to the ligands because the presence of chloride ions, Cl-which caused the complexes to be more acidic, can inhibit bacterial growth.

Original languageMalay
Pages (from-to)560-570
Number of pages11
JournalMalaysian Journal of Analytical Sciences
Volume21
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

Thiosemicarbazones
Chemical properties
Screening
Ligands
Thiones
Thermogravimetric analysis
Metal ions
Rare Earth Metals
Nuclear magnetic resonance
Radiation counters
Bond length
Chemical analysis
Rare earths
Electrolytes
Chlorides
Condensation
Fourier transforms
Ions
Infrared radiation
X rays

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

@article{c255aa8665704d819792b68ec1c4d9c5,
title = "Sintesis, struktur, sifat-sifat kimia, dan penyaringan antibakteria bagi kompleks Sm(III) tiosemikarbazon",
abstract = "Rare earth complexes can exhibit higher coordination numbers while rare earth metals have the ability to form a multitude of geometries with organic ligands. The ligands, [Sm(III) (4Acpy4MTSC)2(4H2O)Cl]Cl2and [Sm(III) (4Acpy4ETSC)(5H2O)Cl2]Cl [4Acpy4MTSC = 4-acetylpyridine 4-methyl-3-thiosemicarbazone; 4Acpy4ETSC = 4-acetylpyridine 4-ethyl-3-thiosemicarbazone] have been synthesised by condensation method. The compounds were structurally characterised by elemental analysis (CHNS), molar conductivity, Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Ultraviolet-Visible (UV-Vis), and Thermo-Gravimetric Analysis (TGA). The elemental analysis for the compounds were in a good agreement with the theoretical values. The molar conductivity of the complexes showed electrolyte behaviour and confirmed the presence of counter ions in the structures. The proposed structures of the compounds have been confirmed by NMR, UV-Vis, and TGA. Based on the analysis, the ligands were coordinated to the metal ions through azomethine N and thione S thus, producing bidentate complexes. From the TGA, it is confirmed that a few water molecules have coordinated with metal ions. The X-ray crystallographic structures for the 4Acpy4ETSC, the C=S bond length is shorter than the single bond C-S which is 1.82 {\AA}. It shows that in the solid state, the ligand exists in the thione form. The 4Acpy4ETSC adopted a monoclinic system, a = 10.5922(7), b = 8.9597(6), c = 13.0407, Z = 4. In vitro antibacterial tests showed that the complexes have an effective inhibitory effect compared to the ligands because the presence of chloride ions, Cl-which caused the complexes to be more acidic, can inhibit bacterial growth.",
keywords = "Antibacterial screening, Samarium(III), Thiosemicarbazone",
author = "{Nur Nadia}, Dzulkifli and {Abdul Aziz}, {Yang Farina} and {Mohd. Yamin}, Bohari and Nazlina Ibrahim",
year = "2017",
doi = "10.17576/mjas-2017-2103-06",
language = "Malay",
volume = "21",
pages = "560--570",
journal = "Malaysian Journal of Analytical Sciences",
issn = "1394-2506",
publisher = "Faculty of Science and Technology, Universiti Kebangsaan Malaysia",
number = "3",

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TY - JOUR

T1 - Sintesis, struktur, sifat-sifat kimia, dan penyaringan antibakteria bagi kompleks Sm(III) tiosemikarbazon

AU - Nur Nadia, Dzulkifli

AU - Abdul Aziz, Yang Farina

AU - Mohd. Yamin, Bohari

AU - Ibrahim, Nazlina

PY - 2017

Y1 - 2017

N2 - Rare earth complexes can exhibit higher coordination numbers while rare earth metals have the ability to form a multitude of geometries with organic ligands. The ligands, [Sm(III) (4Acpy4MTSC)2(4H2O)Cl]Cl2and [Sm(III) (4Acpy4ETSC)(5H2O)Cl2]Cl [4Acpy4MTSC = 4-acetylpyridine 4-methyl-3-thiosemicarbazone; 4Acpy4ETSC = 4-acetylpyridine 4-ethyl-3-thiosemicarbazone] have been synthesised by condensation method. The compounds were structurally characterised by elemental analysis (CHNS), molar conductivity, Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Ultraviolet-Visible (UV-Vis), and Thermo-Gravimetric Analysis (TGA). The elemental analysis for the compounds were in a good agreement with the theoretical values. The molar conductivity of the complexes showed electrolyte behaviour and confirmed the presence of counter ions in the structures. The proposed structures of the compounds have been confirmed by NMR, UV-Vis, and TGA. Based on the analysis, the ligands were coordinated to the metal ions through azomethine N and thione S thus, producing bidentate complexes. From the TGA, it is confirmed that a few water molecules have coordinated with metal ions. The X-ray crystallographic structures for the 4Acpy4ETSC, the C=S bond length is shorter than the single bond C-S which is 1.82 Å. It shows that in the solid state, the ligand exists in the thione form. The 4Acpy4ETSC adopted a monoclinic system, a = 10.5922(7), b = 8.9597(6), c = 13.0407, Z = 4. In vitro antibacterial tests showed that the complexes have an effective inhibitory effect compared to the ligands because the presence of chloride ions, Cl-which caused the complexes to be more acidic, can inhibit bacterial growth.

AB - Rare earth complexes can exhibit higher coordination numbers while rare earth metals have the ability to form a multitude of geometries with organic ligands. The ligands, [Sm(III) (4Acpy4MTSC)2(4H2O)Cl]Cl2and [Sm(III) (4Acpy4ETSC)(5H2O)Cl2]Cl [4Acpy4MTSC = 4-acetylpyridine 4-methyl-3-thiosemicarbazone; 4Acpy4ETSC = 4-acetylpyridine 4-ethyl-3-thiosemicarbazone] have been synthesised by condensation method. The compounds were structurally characterised by elemental analysis (CHNS), molar conductivity, Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Ultraviolet-Visible (UV-Vis), and Thermo-Gravimetric Analysis (TGA). The elemental analysis for the compounds were in a good agreement with the theoretical values. The molar conductivity of the complexes showed electrolyte behaviour and confirmed the presence of counter ions in the structures. The proposed structures of the compounds have been confirmed by NMR, UV-Vis, and TGA. Based on the analysis, the ligands were coordinated to the metal ions through azomethine N and thione S thus, producing bidentate complexes. From the TGA, it is confirmed that a few water molecules have coordinated with metal ions. The X-ray crystallographic structures for the 4Acpy4ETSC, the C=S bond length is shorter than the single bond C-S which is 1.82 Å. It shows that in the solid state, the ligand exists in the thione form. The 4Acpy4ETSC adopted a monoclinic system, a = 10.5922(7), b = 8.9597(6), c = 13.0407, Z = 4. In vitro antibacterial tests showed that the complexes have an effective inhibitory effect compared to the ligands because the presence of chloride ions, Cl-which caused the complexes to be more acidic, can inhibit bacterial growth.

KW - Antibacterial screening

KW - Samarium(III)

KW - Thiosemicarbazone

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DO - 10.17576/mjas-2017-2103-06

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