Sintesis, struktur dan kajian antibakteria kompleks baru ditiokarbamat Sb(III) dan Bi(III)

Translated title of the contribution: Synthesis, structural and antibacterial studies of new dithiocarbamate complexes of Sb(III) and Bi(III)

Nur Amirah Jamaluddin, Ibrahim Baba, Nazlina Ibrahim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Six new dithiocarbamate complexes from three different amines, e.g. N-ethylethanol-, N-butylethyl-and N-benzylmethylamine were successfully prepared using in situ method. All complexes were characterized by elemental analysis, IR, UV-Vis, 13C and 1H NMR. Elemental analysis data (C, H, N and S) showed an agreement with the general formula of MCl(S2CNR'R")2, (M = Sb(III), Bi(III); R' = ethyl, butyl and benzyl; R" = ethanol, ethyl and methyl). The complexes had been characterized by infrared spectroscopy that showed a thioureide bands, ν(C N) in the region of 1427-1490 cm-1 followed by ν(C S) bands that can be seen in the region of 935-1060 cm-1 and ν(M-S) bands existed in the region of 350-392 cm-1. Maximum wavelength absorption for ultraviolet-visible spectroscopy for N C S group was at 254 nm which indicates π→π* transition. Data from 13C NMR showed a signal in the region of 198.39-199.44 ppm that corresponded to the NCS2 group. The crystal structure of bis(N,N'-butylethyldithiocarbamato)chlorido antimony(III), SbCl[S2CN(C4H9)(C2H5)]2 demonstrated a five-coordination geometry, triclinic system, space group P1 with a = 10.0141(8) Å, b = 10.1394(7) Å, c = 11.8665(9) Å, α = 67.960(2)°, β = 87.616(2)° and γ = 80.172(2)°. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests were done using five dithiocarbamate complexes which are BiCl[S2CN(C2H5)(C2H4OH)]2, SbCl[S2CN(C2H5)(C2H4OH)]2, BiCl[S2CN(C4H9)(C2H5)]2, SbCl[S2CN(C4H9)(C2H5)]2, BiCl[S2CN(C7H7)(CH3)]2 towards S. aureus, S. epidermidis, E. aerogenes and E. coli. It was found that all four complexes were active against S. aureus except SbCl[S2CN(C2H5)(C2H4OH)]2 while BiCl[S2CN(C7H7)(CH3)]2 and BiCl[S2CN(CH3)(C6H11)]2 complexes were active against S. epidermidis with MIC value of 5.0 mg/mL and 2.5 mg/mL respectively and MBC value of 5.0 mg/mL for both compounds. Only BiCl[S2CN(C2H5)(C2H4OH)]2 was active against E. aerogenes with MIC, 1.25 mg/mL and MBC, 10 mg/mL. All complexes were less active as antibacterial agent against E. coli strain.

Original languageUndefined/Unknown
Pages (from-to)251-259
Number of pages9
JournalMalaysian Journal of Analytical Sciences
Volume18
Issue number2
Publication statusPublished - 2014

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Escherichia coli
Nuclear magnetic resonance
Antimony
Ultraviolet visible spectroscopy
Chemical analysis
Amines
Infrared spectroscopy
Ethanol
Crystal structure
Anti-Bacterial Agents
Wavelength
Geometry

Keywords

  • Antibacterial
  • Antimony(III)
  • Bismuth(III)
  • Dithiocarbamate

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Sintesis, struktur dan kajian antibakteria kompleks baru ditiokarbamat Sb(III) dan Bi(III). / Jamaluddin, Nur Amirah; Baba, Ibrahim; Ibrahim, Nazlina.

In: Malaysian Journal of Analytical Sciences, Vol. 18, No. 2, 2014, p. 251-259.

Research output: Contribution to journalArticle

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title = "Sintesis, struktur dan kajian antibakteria kompleks baru ditiokarbamat Sb(III) dan Bi(III)",
abstract = "Six new dithiocarbamate complexes from three different amines, e.g. N-ethylethanol-, N-butylethyl-and N-benzylmethylamine were successfully prepared using in situ method. All complexes were characterized by elemental analysis, IR, UV-Vis, 13C and 1H NMR. Elemental analysis data (C, H, N and S) showed an agreement with the general formula of MCl(S2CNR'R{"})2, (M = Sb(III), Bi(III); R' = ethyl, butyl and benzyl; R{"} = ethanol, ethyl and methyl). The complexes had been characterized by infrared spectroscopy that showed a thioureide bands, ν(C N) in the region of 1427-1490 cm-1 followed by ν(C S) bands that can be seen in the region of 935-1060 cm-1 and ν(M-S) bands existed in the region of 350-392 cm-1. Maximum wavelength absorption for ultraviolet-visible spectroscopy for N C S group was at 254 nm which indicates π→π* transition. Data from 13C NMR showed a signal in the region of 198.39-199.44 ppm that corresponded to the NCS2 group. The crystal structure of bis(N,N'-butylethyldithiocarbamato)chlorido antimony(III), SbCl[S2CN(C4H9)(C2H5)]2 demonstrated a five-coordination geometry, triclinic system, space group P1 with a = 10.0141(8) {\AA}, b = 10.1394(7) {\AA}, c = 11.8665(9) {\AA}, α = 67.960(2)°, β = 87.616(2)° and γ = 80.172(2)°. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests were done using five dithiocarbamate complexes which are BiCl[S2CN(C2H5)(C2H4OH)]2, SbCl[S2CN(C2H5)(C2H4OH)]2, BiCl[S2CN(C4H9)(C2H5)]2, SbCl[S2CN(C4H9)(C2H5)]2, BiCl[S2CN(C7H7)(CH3)]2 towards S. aureus, S. epidermidis, E. aerogenes and E. coli. It was found that all four complexes were active against S. aureus except SbCl[S2CN(C2H5)(C2H4OH)]2 while BiCl[S2CN(C7H7)(CH3)]2 and BiCl[S2CN(CH3)(C6H11)]2 complexes were active against S. epidermidis with MIC value of 5.0 mg/mL and 2.5 mg/mL respectively and MBC value of 5.0 mg/mL for both compounds. Only BiCl[S2CN(C2H5)(C2H4OH)]2 was active against E. aerogenes with MIC, 1.25 mg/mL and MBC, 10 mg/mL. All complexes were less active as antibacterial agent against E. coli strain.",
keywords = "Antibacterial, Antimony(III), Bismuth(III), Dithiocarbamate",
author = "Jamaluddin, {Nur Amirah} and Ibrahim Baba and Nazlina Ibrahim",
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journal = "Malaysian Journal of Analytical Sciences",
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publisher = "Faculty of Science and Technology, Universiti Kebangsaan Malaysia",
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TY - JOUR

T1 - Sintesis, struktur dan kajian antibakteria kompleks baru ditiokarbamat Sb(III) dan Bi(III)

AU - Jamaluddin, Nur Amirah

AU - Baba, Ibrahim

AU - Ibrahim, Nazlina

PY - 2014

Y1 - 2014

N2 - Six new dithiocarbamate complexes from three different amines, e.g. N-ethylethanol-, N-butylethyl-and N-benzylmethylamine were successfully prepared using in situ method. All complexes were characterized by elemental analysis, IR, UV-Vis, 13C and 1H NMR. Elemental analysis data (C, H, N and S) showed an agreement with the general formula of MCl(S2CNR'R")2, (M = Sb(III), Bi(III); R' = ethyl, butyl and benzyl; R" = ethanol, ethyl and methyl). The complexes had been characterized by infrared spectroscopy that showed a thioureide bands, ν(C N) in the region of 1427-1490 cm-1 followed by ν(C S) bands that can be seen in the region of 935-1060 cm-1 and ν(M-S) bands existed in the region of 350-392 cm-1. Maximum wavelength absorption for ultraviolet-visible spectroscopy for N C S group was at 254 nm which indicates π→π* transition. Data from 13C NMR showed a signal in the region of 198.39-199.44 ppm that corresponded to the NCS2 group. The crystal structure of bis(N,N'-butylethyldithiocarbamato)chlorido antimony(III), SbCl[S2CN(C4H9)(C2H5)]2 demonstrated a five-coordination geometry, triclinic system, space group P1 with a = 10.0141(8) Å, b = 10.1394(7) Å, c = 11.8665(9) Å, α = 67.960(2)°, β = 87.616(2)° and γ = 80.172(2)°. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests were done using five dithiocarbamate complexes which are BiCl[S2CN(C2H5)(C2H4OH)]2, SbCl[S2CN(C2H5)(C2H4OH)]2, BiCl[S2CN(C4H9)(C2H5)]2, SbCl[S2CN(C4H9)(C2H5)]2, BiCl[S2CN(C7H7)(CH3)]2 towards S. aureus, S. epidermidis, E. aerogenes and E. coli. It was found that all four complexes were active against S. aureus except SbCl[S2CN(C2H5)(C2H4OH)]2 while BiCl[S2CN(C7H7)(CH3)]2 and BiCl[S2CN(CH3)(C6H11)]2 complexes were active against S. epidermidis with MIC value of 5.0 mg/mL and 2.5 mg/mL respectively and MBC value of 5.0 mg/mL for both compounds. Only BiCl[S2CN(C2H5)(C2H4OH)]2 was active against E. aerogenes with MIC, 1.25 mg/mL and MBC, 10 mg/mL. All complexes were less active as antibacterial agent against E. coli strain.

AB - Six new dithiocarbamate complexes from three different amines, e.g. N-ethylethanol-, N-butylethyl-and N-benzylmethylamine were successfully prepared using in situ method. All complexes were characterized by elemental analysis, IR, UV-Vis, 13C and 1H NMR. Elemental analysis data (C, H, N and S) showed an agreement with the general formula of MCl(S2CNR'R")2, (M = Sb(III), Bi(III); R' = ethyl, butyl and benzyl; R" = ethanol, ethyl and methyl). The complexes had been characterized by infrared spectroscopy that showed a thioureide bands, ν(C N) in the region of 1427-1490 cm-1 followed by ν(C S) bands that can be seen in the region of 935-1060 cm-1 and ν(M-S) bands existed in the region of 350-392 cm-1. Maximum wavelength absorption for ultraviolet-visible spectroscopy for N C S group was at 254 nm which indicates π→π* transition. Data from 13C NMR showed a signal in the region of 198.39-199.44 ppm that corresponded to the NCS2 group. The crystal structure of bis(N,N'-butylethyldithiocarbamato)chlorido antimony(III), SbCl[S2CN(C4H9)(C2H5)]2 demonstrated a five-coordination geometry, triclinic system, space group P1 with a = 10.0141(8) Å, b = 10.1394(7) Å, c = 11.8665(9) Å, α = 67.960(2)°, β = 87.616(2)° and γ = 80.172(2)°. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests were done using five dithiocarbamate complexes which are BiCl[S2CN(C2H5)(C2H4OH)]2, SbCl[S2CN(C2H5)(C2H4OH)]2, BiCl[S2CN(C4H9)(C2H5)]2, SbCl[S2CN(C4H9)(C2H5)]2, BiCl[S2CN(C7H7)(CH3)]2 towards S. aureus, S. epidermidis, E. aerogenes and E. coli. It was found that all four complexes were active against S. aureus except SbCl[S2CN(C2H5)(C2H4OH)]2 while BiCl[S2CN(C7H7)(CH3)]2 and BiCl[S2CN(CH3)(C6H11)]2 complexes were active against S. epidermidis with MIC value of 5.0 mg/mL and 2.5 mg/mL respectively and MBC value of 5.0 mg/mL for both compounds. Only BiCl[S2CN(C2H5)(C2H4OH)]2 was active against E. aerogenes with MIC, 1.25 mg/mL and MBC, 10 mg/mL. All complexes were less active as antibacterial agent against E. coli strain.

KW - Antibacterial

KW - Antimony(III)

KW - Bismuth(III)

KW - Dithiocarbamate

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