Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes

Najma Sultana, Muhammad Saeed Arayne, Syeda Bushra Shakeb Rizvi, Urooj Haroon, Osman Mesaik Mohammed Ahmed Hassan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In the study presented levofloxacin metal complexes were synthesized with transition metal ions (MnII, CoII, NiII, CuII, and ZnII) and their structure was elucidated through elemental analysis. Further characterization of these complexes was performed by physiochemical and spectroscopic techniques (FT-IR, 1H NMR). These investigations suggest that levofloxacin interacts with the metal ions as a monoanionic bidentate ligand bound to the metal through the pyridone and one carboxylate oxygen atoms having [M(Levo)2(H2O) 2]·nH2O formula where M = metal ions. The antibacterial activity of the complexes was tested on eleven different microorganisms. The complexes showed either comparable or increased antibacterial profile in comparison to the parent. Moreover, the immunomodulatory activity of complexes was also tested by means of evaluating their effect on oxidative burst activity in whole blood phagocytes, measuring inhibition of (PHA)-induced T-cell proliferation and cytotoxicity.

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalMedicinal Chemistry Research
Volume22
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Fingerprint

Levofloxacin
Coordination Complexes
Metal ions
Metals
Ions
Pyridones
T-cells
Cell proliferation
Cytotoxicity
Microorganisms
Transition metals
Respiratory Burst
Blood
Phagocytes
Nuclear magnetic resonance
Oxygen
Ligands
Atoms
Cell Proliferation
Chemical analysis

Keywords

  • Antibacterial profile
  • Levofloxacin
  • Oxidative burst activity
  • T-cell proliferation
  • Transition metal complexes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Sultana, N., Arayne, M. S., Rizvi, S. B. S., Haroon, U., & Mohammed Ahmed Hassan, O. M. (2013). Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes. Medicinal Chemistry Research, 22(3), 1371-1377. https://doi.org/10.1007/s00044-012-0132-9

Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes. / Sultana, Najma; Arayne, Muhammad Saeed; Rizvi, Syeda Bushra Shakeb; Haroon, Urooj; Mohammed Ahmed Hassan, Osman Mesaik.

In: Medicinal Chemistry Research, Vol. 22, No. 3, 03.2013, p. 1371-1377.

Research output: Contribution to journalArticle

Sultana, N, Arayne, MS, Rizvi, SBS, Haroon, U & Mohammed Ahmed Hassan, OM 2013, 'Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes', Medicinal Chemistry Research, vol. 22, no. 3, pp. 1371-1377. https://doi.org/10.1007/s00044-012-0132-9
Sultana, Najma ; Arayne, Muhammad Saeed ; Rizvi, Syeda Bushra Shakeb ; Haroon, Urooj ; Mohammed Ahmed Hassan, Osman Mesaik. / Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes. In: Medicinal Chemistry Research. 2013 ; Vol. 22, No. 3. pp. 1371-1377.
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