Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An efficient and green method of synthesizing phthalide-fused indoline, 3-[(1,3,3-Trimethylindolin-2-ylidene)methyl]isobenzofuran-1(3H)-one (3) has been developed by the coupling reaction of 1,3,3-Trimethyl-2-methyleneindoline, 1 and phthalaldehydic acid, 2 under solvent-free domestic microwave irradiation. The compound was produced with an excellent yield (98 %) and at a shorter reaction time (5min) as compared to the conventional method. Compound 3 was fully characterized by analytical and spectral methods. Preliminary binding study of 3 towards different types of metal cations was done by "naked eye" colorimetric detection and UV-vis spectrophotometer. Compound 3 exhibits good selectivity and sensitivity for Sn2+ compared to other metal cations.

Original languageEnglish
Title of host publication2017 UKM FST Postgraduate Colloquium
Subtitle of host publicationProceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1940
ISBN (Electronic)9780735416321
DOIs
Publication statusPublished - 4 Apr 2018
Event2017 UKM FST Postgraduate Colloquium - Selangor, Malaysia
Duration: 12 Jul 201713 Jul 2017

Other

Other2017 UKM FST Postgraduate Colloquium
CountryMalaysia
CitySelangor
Period12/7/1713/7/17

Fingerprint

microwaves
cations
irradiation
spectral methods
spectrophotometers
synthesis
reaction time
metals
selectivity
acids
sensitivity

Keywords

  • Binding study
  • Green synthesis
  • Indoline
  • Metal cations
  • Phthalide

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Ling, S. W. S., Latip, J., Hassan, N. I., & Hasbullah, S. A. (2018). Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations. In 2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium (Vol. 1940). [020102] American Institute of Physics Inc.. https://doi.org/10.1063/1.5028017

Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations. / Ling, Sheryn Wong Shue; Latip, Jalifah; Hassan, Nurul Izzaty; Hasbullah, Siti Aishah.

2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium. Vol. 1940 American Institute of Physics Inc., 2018. 020102.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ling, SWS, Latip, J, Hassan, NI & Hasbullah, SA 2018, Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations. in 2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium. vol. 1940, 020102, American Institute of Physics Inc., 2017 UKM FST Postgraduate Colloquium, Selangor, Malaysia, 12/7/17. https://doi.org/10.1063/1.5028017
Ling SWS, Latip J, Hassan NI, Hasbullah SA. Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations. In 2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium. Vol. 1940. American Institute of Physics Inc. 2018. 020102 https://doi.org/10.1063/1.5028017
Ling, Sheryn Wong Shue ; Latip, Jalifah ; Hassan, Nurul Izzaty ; Hasbullah, Siti Aishah. / Synthesis of phthalide-fused indoline by microwave irradiation and preliminary binding study with metal cations. 2017 UKM FST Postgraduate Colloquium: Proceedings of the University Kebangsaan Malaysia, Faculty of Science and Technology 2017 Postgraduate Colloquium. Vol. 1940 American Institute of Physics Inc., 2018.
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