Synthesis, characterization, antibacterial, antifungal and immunomodulating activities of gatifloxacin-metal complexes

Najma Sultana, Asia Naz, M. Saeed Arayne, Osman Mesaik Mohammed Ahmed Hassan

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Gatifloxacin is a potent fluoroquinolone antibacterial agent. It is reported and our previous work has also proved that availability of gatifloxacin is reduced by co-administration of metallic supplements. For better understanding of these interactions, complexes of gatifloxacin were synthesized with Mg(II), Ca(II), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) (usually present in human body) and their structures were established with the help of spectroscopic studies like IR, UV, and NMR. The IR spectra of the complexes suggest that the gatifloxacin behaves as a monoanionic bidentate ligand. In vitro antibacterial, antifungal, anti-inflammatory and immunosuppressive activities of the gatifloxacin and the complexes were tested. GTX-Ni and GTX-Cu has excellent anti-inflammatory activity.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Molecular Structure
Volume969
Issue number1-3
DOIs
Publication statusPublished - 22 Apr 2010
Externally publishedYes

Fingerprint

Coordination Complexes
Anti-Inflammatory Agents
Fluoroquinolones
Immunosuppressive Agents
Nuclear magnetic resonance
gatifloxacin
Availability
Anti-Bacterial Agents
Ligands

Keywords

  • Anti-inflammatory and immunosuppressive activities
  • Antibacterial studies
  • Gatifloxacin
  • Metal complexes
  • Spectroscopic techniques

ASJC Scopus subject areas

  • Spectroscopy
  • Analytical Chemistry
  • Inorganic Chemistry
  • Organic Chemistry

Cite this

Synthesis, characterization, antibacterial, antifungal and immunomodulating activities of gatifloxacin-metal complexes. / Sultana, Najma; Naz, Asia; Arayne, M. Saeed; Mohammed Ahmed Hassan, Osman Mesaik.

In: Journal of Molecular Structure, Vol. 969, No. 1-3, 22.04.2010, p. 17-24.

Research output: Contribution to journalArticle

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