Synthesis, characterization, antibacterial and anti-inflammatory activities of enoxacin metal complexes

Saeed Arayne, Najma Sultana, Urooj Haroon, Osman Mesaik Mohammed Ahmed Hassan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [ M(eno)2 (H2O)2 ]3H2O (M=CuII, NiII or Mn II) and [M(eno) (H2O)2] Cl·4H2O (M = Fe III) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by Mn II and Cu II complexes exhibited potential to mediate anti-inflammatory response.

Original languageEnglish
Article number914105
JournalBioinorganic Chemistry and Applications
Volume2009
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Enoxacin
Coordination Complexes
Anti-Inflammatory Agents
Metals
Spectroscopic analysis
Microorganisms
Transition metals
Reactive Oxygen Species
Ligands
Chemical analysis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Synthesis, characterization, antibacterial and anti-inflammatory activities of enoxacin metal complexes. / Arayne, Saeed; Sultana, Najma; Haroon, Urooj; Mohammed Ahmed Hassan, Osman Mesaik.

In: Bioinorganic Chemistry and Applications, Vol. 2009, 914105, 2009.

Research output: Contribution to journalArticle

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