Synthesis, characterization and biological activity of some new 1,2,4-triazine derivatives

Jumat Salimon, Nadia Salih

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The title compound 2-(4-(anthracen-9(10H)-ylideneamino)-4-(1,6-dihydro-1,2,4-triazin-5(2 H)-one)pyridine 6, molecular formula C29H43N5O, was obtained through a multi steps reactions using tricyclic ketone, anthrone, as starting material. All the newly synthesized compounds were characterized using spectroscopic methods such as FTIR, 1HNMR, 13CNMR and elemental analysis. All synthesized compounds were primary in vitro screened for their antibacterial activity against Gram-positive (Staphylococcus aureus ATCC 6538p, Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis PTCC 1023) and Gram-negative (Escherichia coil ATCC 8739, Klebsiella pneumoniae ATCC 10031, and Pseudomonas aeruginosa ATCC 9027) bacteria by the drug diffusion method.

Original languageEnglish
Pages (from-to)1041-1045
Number of pages5
JournalInternational Journal of PharmTech Research
Volume2
Issue number2
Publication statusPublished - Apr 2010

Fingerprint

Escherichia
Staphylococcus epidermidis
Klebsiella pneumoniae
Fourier Transform Infrared Spectroscopy
Bacillus subtilis
Ketones
Pseudomonas aeruginosa
Staphylococcus aureus
Bacteria
Pharmaceutical Preparations
1,2,4-triazine
pyridine
In Vitro Techniques
anthrone

Keywords

  • 1,2,4-triazine
  • Biological activity
  • Carbohydrazides
  • Spectral studies
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Synthesis, characterization and biological activity of some new 1,2,4-triazine derivatives. / Salimon, Jumat; Salih, Nadia.

In: International Journal of PharmTech Research, Vol. 2, No. 2, 04.2010, p. 1041-1045.

Research output: Contribution to journalArticle

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