Synthesis, characterization and biological activities of organotin(IV) complexes with vitamin K3-2-hydrazinopyridine

X-ray crystal structure of vitamin K3-2-hydrazinopyridine [VHzP]

M. A. Affan, Dayang Norafizan A Chee, Fasihuddin B. Ahmad, J. Ismail, Bohari Mohd. Yamin, Ramli B. Hitam

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Six new organotin(IV) complexes were synthesized by direct reaction of RSnCl3 (R= Me, Bu and Ph) or R2SnCl2 (R= Me, Bu and Ph) and vitamin K3-2-hydrazinopyridine [VHzP, (1)] in Schlenk round bottom flask under nitrogen atmosphere. All organotin(IV) complexes (2-7) have been characterized by elemental analyses, molar conductivity, UV-Visible, IR and 1H NMR spectral studies. The organotin(IV) complexes (2-7) are non-electrolytic in nature. The crystal structure of ligand (1) has also been determined by X-ray crystallography diffraction analysis. The ligand (1) and its organotin(IV) complexes (2-7) have also been tested for their toxicity and anti-termitic potential and found to be moderately active against Artemia salina and Coptotermes sp.

Original languageEnglish
Pages (from-to)158-172
Number of pages15
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume1
Issue number4
Publication statusPublished - Oct 2010

Fingerprint

Vitamin K 3
Bioactivity
Crystal structure
X-Rays
Ligands
Artemia
X rays
X ray crystallography
X Ray Crystallography
Atmosphere
X-Ray Diffraction
Toxicity
Nitrogen
Diffraction
Nuclear magnetic resonance
2-hydrazinopyridine
Salinum
Proton Magnetic Resonance Spectroscopy

Keywords

  • Anti-termitic
  • Organotin(IV) complexes
  • Toxicity
  • Vitamin K-2-hydrazinopyridine

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Synthesis, characterization and biological activities of organotin(IV) complexes with vitamin K3-2-hydrazinopyridine : X-ray crystal structure of vitamin K3-2-hydrazinopyridine [VHzP]. / Affan, M. A.; Chee, Dayang Norafizan A; Ahmad, Fasihuddin B.; Ismail, J.; Mohd. Yamin, Bohari; Hitam, Ramli B.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 1, No. 4, 10.2010, p. 158-172.

Research output: Contribution to journalArticle

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