Synthesis, characterization and biological activities of cetirizine analogues

Najma Sultana, M. Saeed Arayne, Hina Shamshad, Agha Zeeshan Mirza, Malik Asia Naz, Beenish Fatima, M. Asif, Osman Mesaik Mohammed Ahmed Hassan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cetirizine second generation H 1-receptor antagonist is an acid metabolite of hydroxyzine. Present work was based on six new analogues of cetirizine having nucleophilic substitution reaction synthetic pathway. The reactions were proceeded by replacing the scaffold on the cetirizine moiety using nucleophilic substitution reaction. The structures of analogues were confirmed using UV, IR, 1H NMR and mass spectroscopic techniques. The analogues were tested for the anti-inflammatory activities on cellular immune response. Oxidative burst response of phagocytes after exposure to the analogues was found to exhibit moderate to significant inhibitory activity (23 to

Original languageEnglish
Pages (from-to)317-328
Number of pages12
JournalSpectroscopy
Volume26
Issue number4-5
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Cetirizine
Bioactivity
Substitution reactions
Hydroxyzine
Metabolites
Scaffolds
Anti-Inflammatory Agents
Nuclear magnetic resonance
Acids

Keywords

  • anti-inflammatory activities
  • Cetirizine
  • H-1-receptor antagonist
  • oxidative burst

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Sultana, N., Arayne, M. S., Shamshad, H., Mirza, A. Z., Naz, M. A., Fatima, B., ... Mohammed Ahmed Hassan, O. M. (2011). Synthesis, characterization and biological activities of cetirizine analogues. Spectroscopy, 26(4-5), 317-328. https://doi.org/10.3233/SPE-2011-0537

Synthesis, characterization and biological activities of cetirizine analogues. / Sultana, Najma; Arayne, M. Saeed; Shamshad, Hina; Mirza, Agha Zeeshan; Naz, Malik Asia; Fatima, Beenish; Asif, M.; Mohammed Ahmed Hassan, Osman Mesaik.

In: Spectroscopy, Vol. 26, No. 4-5, 2011, p. 317-328.

Research output: Contribution to journalArticle

Sultana, N, Arayne, MS, Shamshad, H, Mirza, AZ, Naz, MA, Fatima, B, Asif, M & Mohammed Ahmed Hassan, OM 2011, 'Synthesis, characterization and biological activities of cetirizine analogues', Spectroscopy, vol. 26, no. 4-5, pp. 317-328. https://doi.org/10.3233/SPE-2011-0537
Sultana N, Arayne MS, Shamshad H, Mirza AZ, Naz MA, Fatima B et al. Synthesis, characterization and biological activities of cetirizine analogues. Spectroscopy. 2011;26(4-5):317-328. https://doi.org/10.3233/SPE-2011-0537
Sultana, Najma ; Arayne, M. Saeed ; Shamshad, Hina ; Mirza, Agha Zeeshan ; Naz, Malik Asia ; Fatima, Beenish ; Asif, M. ; Mohammed Ahmed Hassan, Osman Mesaik. / Synthesis, characterization and biological activities of cetirizine analogues. In: Spectroscopy. 2011 ; Vol. 26, No. 4-5. pp. 317-328.
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