Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex

Kar Beng Chew, M. T H Tarafder, Karen A. Crouse, A. M. Ali, Bohari Mohd. Yamin, H. K. Fun

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Condensation of SMDTC with 2-furyl-methylketone and 5-methyl-2-furaldehyde gave isomeric Schiff bases, (NS) and (NS). The metal complexes of these uninegatively charged bidentate Schiff base ligands with cadmium, tin, iron, lead and cobalt have been prepared. The complexes have been characterized by a variety of physico-chemical techniques. X-ray crystallographic analysis shows that the Cd(II) complex, bis[S-methyl-β-N-(2-furylmethylketone) dithiocarbazato]cadmium(II), consists of two molecules with distorted octahedral structure. The Co(II) complexes are paramagnetic with a square-planar stereochemistry. The diamagnetic Sn(II), Fe(III) and Pb(II) complexes also have square-planar structures while the diamagnetic [Cd(NS) 2]·3H2O complex is tetrahedral. The [Cd(NS )2]·3H2O, [Sn(NS)2] and [Co(NS)2] showed clear inhibition of almost all bacteria and fungi tested However, [Cd(NS)2], [Fe(NS)]Cl2, [Pb(NS) 2] and [Pb(NS)2] were inactive against all bacteria assayed while [Cd(NS)2], [Fe(NS)]Cl2 and [Pb(NS)2] showed clear inhibition of some fungi. The [Cd(NS) 2], [Cd(NS)2]·3H2O and [Co(NS)2] were found to be very active against Human cell T-lymphoblastic leukemia (CEM-SS) and cervical cancer cells (HELA) with CD 50 values between 1.8 and 3.6 μlcm-3.

Original languageEnglish
Pages (from-to)1385-1392
Number of pages8
JournalPolyhedron
Volume23
Issue number8
DOIs
Publication statusPublished - 6 May 2004

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Schiff Bases
fungi
Coordination Complexes
Metal complexes
Bioactivity
Fungi
Cadmium
cadmium
bacteria
imines
Bacteria
Cells
X-Rays
X rays
Stereochemistry
leukemias
Tin
planar structures
stereochemistry
synthesis

Keywords

  • Crystal structure of Cd(II) complex
  • Dithiocarbazate derivatives
  • NS Schiff base
  • S-methyldithiocarbazate (SMDTC)

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex. / Chew, Kar Beng; Tarafder, M. T H; Crouse, Karen A.; Ali, A. M.; Mohd. Yamin, Bohari; Fun, H. K.

In: Polyhedron, Vol. 23, No. 8, 06.05.2004, p. 1385-1392.

Research output: Contribution to journalArticle

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T1 - Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex

AU - Chew, Kar Beng

AU - Tarafder, M. T H

AU - Crouse, Karen A.

AU - Ali, A. M.

AU - Mohd. Yamin, Bohari

AU - Fun, H. K.

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AB - Condensation of SMDTC with 2-furyl-methylketone and 5-methyl-2-furaldehyde gave isomeric Schiff bases, (NS) and (NS′). The metal complexes of these uninegatively charged bidentate Schiff base ligands with cadmium, tin, iron, lead and cobalt have been prepared. The complexes have been characterized by a variety of physico-chemical techniques. X-ray crystallographic analysis shows that the Cd(II) complex, bis[S-methyl-β-N-(2-furylmethylketone) dithiocarbazato]cadmium(II), consists of two molecules with distorted octahedral structure. The Co(II) complexes are paramagnetic with a square-planar stereochemistry. The diamagnetic Sn(II), Fe(III) and Pb(II) complexes also have square-planar structures while the diamagnetic [Cd(NS′) 2]·3H2O complex is tetrahedral. The [Cd(NS ′)2]·3H2O, [Sn(NS)2] and [Co(NS)2] showed clear inhibition of almost all bacteria and fungi tested However, [Cd(NS)2], [Fe(NS)]Cl2, [Pb(NS) 2] and [Pb(NS′)2] were inactive against all bacteria assayed while [Cd(NS)2], [Fe(NS)]Cl2 and [Pb(NS)2] showed clear inhibition of some fungi. The [Cd(NS) 2], [Cd(NS′)2]·3H2O and [Co(NS)2] were found to be very active against Human cell T-lymphoblastic leukemia (CEM-SS) and cervical cancer cells (HELA) with CD 50 values between 1.8 and 3.6 μlcm-3.

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KW - S-methyldithiocarbazate (SMDTC)

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