Synthesis, characterization and antitumor activity of new organotin(IV) methoxyethyldithiocarbamate complexes

Normah Awang, Kamaludin Nurul Farahana, Ibrahim Baba, Chan Kok Meng, Nor Fadilah Rajaajab, Asmah Hamid

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two new organotin(IV) dithiocarbamate complexes of the type R3SnL and R2SnL2 (L = methoxyethyldithiocarbamate and R = C6H5 or C4H9) were synthesized in good yields. The organotin complexes were suitably characterized by elemental analysis, FT-IR, 1H, and 13C NMR spectroscopies. These complexes were prepared in situ. Elemental analysis data (carbon, hydrogen, nitrogen, and sulfur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for ν(C=N), ν(C=S), and n(Sn-S) in the region of 1450-1463, 992-994, and 324-326 cm-1 respectively. Data for 13C NMR spectroscopy showed an important peak in the region of δC 197-201 ppm that corresponded to the NCS2 group. These complexes were evaluated for their in vitro anti proliferative activities against HL-60 cell lines. The results showed that both of these complexes had high cytotoxicities toward HL-60 cell lines with the IC50 values below 1 μM.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalOriental Journal of Chemistry
Volume32
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

HL-60 Cells
Nuclear magnetic resonance spectroscopy
nuclear magnetic resonance
Magnetic Resonance Spectroscopy
spectroscopy
Cells
Cell Line
Cytotoxicity
Chemical analysis
Sulfur
Inhibitory Concentration 50
Hydrogen
Nitrogen
Carbon
sulfur
hydrogen
Infrared radiation
nitrogen
carbon
Carbon-13 Magnetic Resonance Spectroscopy

Keywords

  • Cytotoxicity
  • Dithiocarbamate
  • Organotin(IV)
  • Spectroscopy
  • Synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Drug Discovery

Cite this

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title = "Synthesis, characterization and antitumor activity of new organotin(IV) methoxyethyldithiocarbamate complexes",
abstract = "Two new organotin(IV) dithiocarbamate complexes of the type R3SnL and R2SnL2 (L = methoxyethyldithiocarbamate and R = C6H5 or C4H9) were synthesized in good yields. The organotin complexes were suitably characterized by elemental analysis, FT-IR, 1H, and 13C NMR spectroscopies. These complexes were prepared in situ. Elemental analysis data (carbon, hydrogen, nitrogen, and sulfur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for ν(C=N), ν(C=S), and n(Sn-S) in the region of 1450-1463, 992-994, and 324-326 cm-1 respectively. Data for 13C NMR spectroscopy showed an important peak in the region of δC 197-201 ppm that corresponded to the NCS2 group. These complexes were evaluated for their in vitro anti proliferative activities against HL-60 cell lines. The results showed that both of these complexes had high cytotoxicities toward HL-60 cell lines with the IC50 values below 1 μM.",
keywords = "Cytotoxicity, Dithiocarbamate, Organotin(IV), Spectroscopy, Synthesis",
author = "Normah Awang and {Nurul Farahana}, Kamaludin and Ibrahim Baba and {Kok Meng}, Chan and Rajaajab, {Nor Fadilah} and Asmah Hamid",
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journal = "Oriental Journal of Chemistry",
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TY - JOUR

T1 - Synthesis, characterization and antitumor activity of new organotin(IV) methoxyethyldithiocarbamate complexes

AU - Awang, Normah

AU - Nurul Farahana, Kamaludin

AU - Baba, Ibrahim

AU - Kok Meng, Chan

AU - Rajaajab, Nor Fadilah

AU - Hamid, Asmah

PY - 2016

Y1 - 2016

N2 - Two new organotin(IV) dithiocarbamate complexes of the type R3SnL and R2SnL2 (L = methoxyethyldithiocarbamate and R = C6H5 or C4H9) were synthesized in good yields. The organotin complexes were suitably characterized by elemental analysis, FT-IR, 1H, and 13C NMR spectroscopies. These complexes were prepared in situ. Elemental analysis data (carbon, hydrogen, nitrogen, and sulfur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for ν(C=N), ν(C=S), and n(Sn-S) in the region of 1450-1463, 992-994, and 324-326 cm-1 respectively. Data for 13C NMR spectroscopy showed an important peak in the region of δC 197-201 ppm that corresponded to the NCS2 group. These complexes were evaluated for their in vitro anti proliferative activities against HL-60 cell lines. The results showed that both of these complexes had high cytotoxicities toward HL-60 cell lines with the IC50 values below 1 μM.

AB - Two new organotin(IV) dithiocarbamate complexes of the type R3SnL and R2SnL2 (L = methoxyethyldithiocarbamate and R = C6H5 or C4H9) were synthesized in good yields. The organotin complexes were suitably characterized by elemental analysis, FT-IR, 1H, and 13C NMR spectroscopies. These complexes were prepared in situ. Elemental analysis data (carbon, hydrogen, nitrogen, and sulfur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for ν(C=N), ν(C=S), and n(Sn-S) in the region of 1450-1463, 992-994, and 324-326 cm-1 respectively. Data for 13C NMR spectroscopy showed an important peak in the region of δC 197-201 ppm that corresponded to the NCS2 group. These complexes were evaluated for their in vitro anti proliferative activities against HL-60 cell lines. The results showed that both of these complexes had high cytotoxicities toward HL-60 cell lines with the IC50 values below 1 μM.

KW - Cytotoxicity

KW - Dithiocarbamate

KW - Organotin(IV)

KW - Spectroscopy

KW - Synthesis

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