Sintesis, pencirian dan kajian antibakteria kompleks kuprum (II) tiosemikarbazon

Translated title of the contribution: Synthesis, characterization and antibacterial study of copper (II) complexes of thiosemicarbazones

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Reaction of CuCl2.2H2O with 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-ethyl thiosemicarbazone, (HL1) and 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-phenylthiosemicarbazone, (HL2) in ethanol produced the compounds [Cu(L1)Cl]2.2H2O (1) and [Cu(HL)Cl2] (2) respectively. The ligands and complexes were characterized by elemental analysis (C, H, N, and S), FT-IR, UV-visible, magnetic susceptibility and molar conductance. The thiosemicarbazone is a tridentate ligand coordinated via the pyridine nitrogen atom, the azomethine nitrogen atom and the sulfur atom. The thiosemicarbazones may coordinate as neutral oranionic ligands. The physicochemical and spectral data indicate a square pyramidal geometry for copper (II) atoms. The thiosemicarbazone ligands show moderate activity against bacteria MRSA and B.subtilis, while the copper(II) complexes were very active against MRSA, B.subtilis and B.thuringiensis and show moderate activity against S.aureus and E.coli.

Original languageMalay
Pages (from-to)1171-1178
Number of pages8
JournalMalaysian Journal of Analytical Sciences
Volume19
Issue number6
Publication statusPublished - 2015

Fingerprint

Thiosemicarbazones
Copper
Ligands
Atoms
Nitrogen
Magnetic susceptibility
Sulfur
Escherichia coli
Bacteria
Ethanol
Geometry
Chemical analysis
pyridine-2-carboxaldehyde

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Sintesis, pencirian dan kajian antibakteria kompleks kuprum (II) tiosemikarbazon. / Abdalla, Omima; Abdul Aziz, Yang Farina; Ibrahim, Nazlina.

In: Malaysian Journal of Analytical Sciences, Vol. 19, No. 6, 2015, p. 1171-1178.

Research output: Contribution to journalArticle

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AB - Reaction of CuCl2.2H2O with 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-ethyl thiosemicarbazone, (HL1) and 6-(3-thienyl) pyridine-2-carboxaldehyde-4N-phenylthiosemicarbazone, (HL2) in ethanol produced the compounds [Cu(L1)Cl]2.2H2O (1) and [Cu(HL)Cl2] (2) respectively. The ligands and complexes were characterized by elemental analysis (C, H, N, and S), FT-IR, UV-visible, magnetic susceptibility and molar conductance. The thiosemicarbazone is a tridentate ligand coordinated via the pyridine nitrogen atom, the azomethine nitrogen atom and the sulfur atom. The thiosemicarbazones may coordinate as neutral oranionic ligands. The physicochemical and spectral data indicate a square pyramidal geometry for copper (II) atoms. The thiosemicarbazone ligands show moderate activity against bacteria MRSA and B.subtilis, while the copper(II) complexes were very active against MRSA, B.subtilis and B.thuringiensis and show moderate activity against S.aureus and E.coli.

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