Sintesis dan kajian biologi sebatian fenilstanum(IV) ditiokarbamat

Translated title of the contribution: Synthesis, characterisation and biological studies of new phenyltin(IV) dithiocarbamate compounds

Amirah Faizah Abdul Muthalib, Ibrahim Baba, Nazlina Ibrahim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nine chlorophenyltin(IV) dithiocarbamate compounds of general formula PhSnCl[S 2CNR’R’’] 2 (R’ = CH3, C 2H5, C7H7 and R” = C2H5, C 6H11, iC3H7, C 7H7) were prepared in one pot reaction of various secondary amine, carbon disulphide and phenyltin(1V) trichloride with the ratio of 2:2:1. These compounds have been characterized by elemental analysis, infrared spectroscopy, ultraviolet spectroscopy, 1H, 13C NMR spectroscopy as well as single crystal X-ray crystallography. Data from X-ray crystallography showed that (C6H5)SnCl[S 2CN(C2H5)(iC3H7)] 2 is six coordinated bonded with two chelating dithiocarbamate ligands in bidentate fashion, methyl-C and chloride atom thus form a distorted octahedral geometry. Five selected compounds, (C 6H5)SnCl[S 2CN(CH3)(C2H5)] 2, (C 6H5)SnCl[S 2CN(CH3)(C6H11)] 2, (C 6H5)SnCl[S 2CN(C 2H5)(iC3H7)] 2, (C6H5)SnCl[S 2CN(C7H7)(iC3H7)]2 and (C 6H5)SnCl[S 2CN(C7H7)2]2 were screened for anticancer activity against Chang liver cells. These compounds were demonstrated no cytotoxic effect for all concentrations under the condition of the study with no IC50 value. The minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) determinations for these five compounds used Escherichia coli and Pseudomonas aeruginosa as Gram negative bacteria together with Staphylococcus aureus and Staphylococcus epidermis as Gram positive bacteria. Compound (C6H5)SnCl[S 2CN(CH3)(C2H5)] 2 was the most active compared to the other compounds by having the lowest MIC values of 1.25 mg/mL and MBC value of 5.0 mg/mL against E. Coli and S. Aureus bacteria. Compounds (C6H5)SnCl[S 2CN(C7H7)(iC3H7)] 2 and (C 6H5)SnCl[S 2CN(C7H7)2] 2 that having a benzyl group showed their MIC and MBC values slightly higher compared to the other compounds againts certain bacteria indicating their low antibacterial activities.

Original languageMalay
Pages (from-to)349-358
Number of pages10
JournalMalaysian Journal of Analytical Sciences
Volume19
Issue number2
Publication statusPublished - 2015

Fingerprint

Bacteria
X ray crystallography
Carbon Disulfide
Chelation
Ultraviolet spectroscopy
Liver
Escherichia coli
Nuclear magnetic resonance spectroscopy
Amines
Chlorides
Infrared spectroscopy
Single crystals
Ligands
Atoms
Geometry
phenyltin
Chemical analysis

Keywords

  • Biological studies
  • Chlorophenyltin(IV)
  • Crystal structure
  • Dithiocarbamate

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Sintesis dan kajian biologi sebatian fenilstanum(IV) ditiokarbamat. / Muthalib, Amirah Faizah Abdul; Baba, Ibrahim; Ibrahim, Nazlina.

In: Malaysian Journal of Analytical Sciences, Vol. 19, No. 2, 2015, p. 349-358.

Research output: Contribution to journalArticle

Muthalib, Amirah Faizah Abdul ; Baba, Ibrahim ; Ibrahim, Nazlina. / Sintesis dan kajian biologi sebatian fenilstanum(IV) ditiokarbamat. In: Malaysian Journal of Analytical Sciences. 2015 ; Vol. 19, No. 2. pp. 349-358.
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