Sintesis, pencirian dan kajian aktiviti antibakteria kompleks Cu(II) tiourea

Translated title of the contribution: Synthesis, characterisation and antibacterial studies of Cu(II) complexes thiourea

Nur Illane Mohamad Halim, Karimah Kassim, Adibatul Husna Fadzil, Bohari Mohd. Yamin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A series of bisthiourea ligands, 1,2-bis(N'-2-methoxybenzoylthioureido)-4-chlorobenzene (TI), 1,2-bis(N'-3-methoxy benzoylthioureido)-4-chlorobenzene (TII) and 1,2-bis(N'-4-methoxybenzoylthioureido)-4-chlorobenzene (TIII) and their Cu(II) complexes have been successfully synthesised. The products have been characterised by elemental analysis (CHNS), IR spectroscopy, 1H and 13C Nuclear Magnetic Resonance (NMR), melting point and magnetic susceptibility determination method. The values of μ eff (B.M) for Cu(II) complexes in the range of 1.23-2.21 B.M reveal that the complexes are square planar geometry. The thiourea ligands along with their respective Cu(II) complexes were screened for their antibacterial activity using disc diffusion method against four strains of bacteria (Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus). Interestingly, compound TIII, Cu(TII) and Cu(TIII) showed the activity against Staphylococcus aureus. The antibacterial activity of their metal complexes is higher than the ligands.

Original languageUndefined/Unknown
Pages (from-to)56-61
Number of pages6
JournalMalaysian Journal of Analytical Sciences
Volume16
Issue number1
Publication statusPublished - 2012

Fingerprint

Thiourea
Ligands
Coordination Complexes
Bacilli
Magnetic susceptibility
Escherichia coli
Melting point
Infrared spectroscopy
Bacteria
Nuclear magnetic resonance
Geometry
Chemical analysis
chlorobenzene

Keywords

  • Antibacterial activity
  • Bisthiourea
  • Spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Halim, N. I. M., Kassim, K., Fadzil, A. H., & Mohd. Yamin, B. (2012). Sintesis, pencirian dan kajian aktiviti antibakteria kompleks Cu(II) tiourea. Malaysian Journal of Analytical Sciences, 16(1), 56-61.

Sintesis, pencirian dan kajian aktiviti antibakteria kompleks Cu(II) tiourea. / Halim, Nur Illane Mohamad; Kassim, Karimah; Fadzil, Adibatul Husna; Mohd. Yamin, Bohari.

In: Malaysian Journal of Analytical Sciences, Vol. 16, No. 1, 2012, p. 56-61.

Research output: Contribution to journalArticle

Halim, NIM, Kassim, K, Fadzil, AH & Mohd. Yamin, B 2012, 'Sintesis, pencirian dan kajian aktiviti antibakteria kompleks Cu(II) tiourea', Malaysian Journal of Analytical Sciences, vol. 16, no. 1, pp. 56-61.
Halim, Nur Illane Mohamad ; Kassim, Karimah ; Fadzil, Adibatul Husna ; Mohd. Yamin, Bohari. / Sintesis, pencirian dan kajian aktiviti antibakteria kompleks Cu(II) tiourea. In: Malaysian Journal of Analytical Sciences. 2012 ; Vol. 16, No. 1. pp. 56-61.
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