Synthesis and swelling behavior of pH-sensitive semi-IPN superabsorbent hydrogels based on poly(acrylic acid) reinforced with cellulose nanocrystals

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Abstract

pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared. Acrylic acid (AA) was subjected to chemical cross-linking using the cross-linking agent MBA (N,N-methylenebisacrylamide) with CNC entrapped in the PAA matrix. The quantity of CNC was varied between 0, 5, 10, 15, 20, and 25 wt %. X-ray diffraction (XRD) data showed an increase in crystallinity with the addition of CNC, while rheology tests demonstrated a significant increase in the storage modulus of the hydrogel with an increase in CNC content. It was found that the hydrogel reached maximum swelling at pH 7. The potential of the resulting hydrogels to act as drug carriers was then evaluated by means of the drug encapsulation efficiency test using theophylline as a model drug. It was observed that 15% CNC/PAA hydrogel showed the potential to be used as drug carrier system.

Original languageEnglish
Article number399
JournalNanomaterials
Volume7
Issue number11
DOIs
Publication statusPublished - 20 Nov 2017

Fingerprint

carbopol 940
Hydrogels
Cellulose
Nanocrystals
Acrylics
Swelling
Hydrogel
Acids
Drug Carriers
Theophylline
Rheology
Encapsulation
Pharmaceutical Preparations
Elastic moduli

Keywords

  • Acrylic acid
  • Cellulose nanocrystals
  • Chemical cross-linking

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)

Cite this

@article{4512428401434ec6abcbe05406b09abf,
title = "Synthesis and swelling behavior of pH-sensitive semi-IPN superabsorbent hydrogels based on poly(acrylic acid) reinforced with cellulose nanocrystals",
abstract = "pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared. Acrylic acid (AA) was subjected to chemical cross-linking using the cross-linking agent MBA (N,N-methylenebisacrylamide) with CNC entrapped in the PAA matrix. The quantity of CNC was varied between 0, 5, 10, 15, 20, and 25 wt {\%}. X-ray diffraction (XRD) data showed an increase in crystallinity with the addition of CNC, while rheology tests demonstrated a significant increase in the storage modulus of the hydrogel with an increase in CNC content. It was found that the hydrogel reached maximum swelling at pH 7. The potential of the resulting hydrogels to act as drug carriers was then evaluated by means of the drug encapsulation efficiency test using theophylline as a model drug. It was observed that 15{\%} CNC/PAA hydrogel showed the potential to be used as drug carrier system.",
keywords = "Acrylic acid, Cellulose nanocrystals, Chemical cross-linking",
author = "Lim, {Lim Sze} and Rosli, {Noor Afizah} and Ishak Ahmad and {Mat Lazim}, {Mohamad Azwani Shah} and {Mohd Amin}, {Mohd Cairul Iqbal}",
year = "2017",
month = "11",
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T1 - Synthesis and swelling behavior of pH-sensitive semi-IPN superabsorbent hydrogels based on poly(acrylic acid) reinforced with cellulose nanocrystals

AU - Lim, Lim Sze

AU - Rosli, Noor Afizah

AU - Ahmad, Ishak

AU - Mat Lazim, Mohamad Azwani Shah

AU - Mohd Amin, Mohd Cairul Iqbal

PY - 2017/11/20

Y1 - 2017/11/20

N2 - pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared. Acrylic acid (AA) was subjected to chemical cross-linking using the cross-linking agent MBA (N,N-methylenebisacrylamide) with CNC entrapped in the PAA matrix. The quantity of CNC was varied between 0, 5, 10, 15, 20, and 25 wt %. X-ray diffraction (XRD) data showed an increase in crystallinity with the addition of CNC, while rheology tests demonstrated a significant increase in the storage modulus of the hydrogel with an increase in CNC content. It was found that the hydrogel reached maximum swelling at pH 7. The potential of the resulting hydrogels to act as drug carriers was then evaluated by means of the drug encapsulation efficiency test using theophylline as a model drug. It was observed that 15% CNC/PAA hydrogel showed the potential to be used as drug carrier system.

AB - pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared. Acrylic acid (AA) was subjected to chemical cross-linking using the cross-linking agent MBA (N,N-methylenebisacrylamide) with CNC entrapped in the PAA matrix. The quantity of CNC was varied between 0, 5, 10, 15, 20, and 25 wt %. X-ray diffraction (XRD) data showed an increase in crystallinity with the addition of CNC, while rheology tests demonstrated a significant increase in the storage modulus of the hydrogel with an increase in CNC content. It was found that the hydrogel reached maximum swelling at pH 7. The potential of the resulting hydrogels to act as drug carriers was then evaluated by means of the drug encapsulation efficiency test using theophylline as a model drug. It was observed that 15% CNC/PAA hydrogel showed the potential to be used as drug carrier system.

KW - Acrylic acid

KW - Cellulose nanocrystals

KW - Chemical cross-linking

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