Abstract
Cancer cells which are large in size are resistant towards radiation therapy due to the presence of large amount of anti-oxidative enzymes and hypoxic cancer cells. Thus radiosensitizer agents have been developed to enhance the therapeutic effect of radiotherapy by increasing the sensitivity of these cancer cells towards radiation. This study is conducted to investigate the radiosensitization properties of radiosensitizer complex containing hydrogen peroxide and sodium hyaluronate. Combination with sodium hyaluronate may decrease reactivity of hydrogen peroxide but maintain the oxygen concentration needed for radiosensitizing effect. HepG2 cancer cells are cultured as the mean of test subject. Cancer cell samples which are targeted and not targeted with these radiosensitizers are irradiated with 2Gy single fractionated dose. Results obtained shows that the cancer cells which are not targeted with radiosensitizers has a cell viability of 98.80±0.37% after a time interval of 48 hours and has even repopulated over 100% after a 72 hour time interval. This shows that the cancer cells are resistant towards radiation. However, when the cancer cells are targeted with radiosensitizers prior to irradiation, there is a reduction of cell viability by 25.50±10.81% and 10.30±5.10% at time intervals of 48 and 72 hours respectively. This indicates that through the use of these radiosensitizers, cancer cells are more sensitive towards radiation.
| Original language | English |
|---|---|
| Title of host publication | 2014 UKM FST Postgraduate Colloquium - Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium |
| Editors | Zahari Ibrahim, Haja Maideen Kader Maideen, Nazlina Ibrahim, Nurul Huda Abd Karim, Taufik Yusof, Fatimah Abdul Razak, Nurulkamal Maseran, Rozida Mohd Khalid, Noor Baa'yah Ibrahim, Hasidah Mohd. Sidek, Mohd Salmi Md Noorani, Norbert Simon |
| Publisher | American Institute of Physics Inc. |
| Pages | 78-81 |
| Number of pages | 4 |
| ISBN (Electronic) | 9780735412507 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
| Event | 2014 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2014 - Selangor, Malaysia Duration: 9 Apr 2014 → 11 Apr 2014 |
Publication series
| Name | AIP Conference Proceedings |
|---|---|
| Volume | 1614 |
| ISSN (Print) | 0094-243X |
| ISSN (Electronic) | 1551-7616 |
Other
| Other | 2014 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2014 |
|---|---|
| Country | Malaysia |
| City | Selangor |
| Period | 9/4/14 → 11/4/14 |
Fingerprint
Keywords
- Cancer
- Cell viability
- Radiation
- Radiosensitizer
- Radiotherapy
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
Synthesis and radiosensitization properties of hydrogen peroxide and sodium hyaluronate complex. / Nur Ratasha, Nur Ratasha Alia; K.P. Kunchi Mohamed, Faizal; Heng, Cheong Kai; Abdul Rahman, Irman; Ahmad, Ainee Fatimah; Mohamad, Hur Munawar Kabir.
2014 UKM FST Postgraduate Colloquium - Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium. ed. / Zahari Ibrahim; Haja Maideen Kader Maideen; Nazlina Ibrahim; Nurul Huda Abd Karim; Taufik Yusof; Fatimah Abdul Razak; Nurulkamal Maseran; Rozida Mohd Khalid; Noor Baa'yah Ibrahim; Hasidah Mohd. Sidek; Mohd Salmi Md Noorani; Norbert Simon. American Institute of Physics Inc., 2014. p. 78-81 (AIP Conference Proceedings; Vol. 1614).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Synthesis and radiosensitization properties of hydrogen peroxide and sodium hyaluronate complex
AU - Nur Ratasha, Nur Ratasha Alia
AU - K.P. Kunchi Mohamed, Faizal
AU - Heng, Cheong Kai
AU - Abdul Rahman, Irman
AU - Ahmad, Ainee Fatimah
AU - Mohamad, Hur Munawar Kabir
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Cancer cells which are large in size are resistant towards radiation therapy due to the presence of large amount of anti-oxidative enzymes and hypoxic cancer cells. Thus radiosensitizer agents have been developed to enhance the therapeutic effect of radiotherapy by increasing the sensitivity of these cancer cells towards radiation. This study is conducted to investigate the radiosensitization properties of radiosensitizer complex containing hydrogen peroxide and sodium hyaluronate. Combination with sodium hyaluronate may decrease reactivity of hydrogen peroxide but maintain the oxygen concentration needed for radiosensitizing effect. HepG2 cancer cells are cultured as the mean of test subject. Cancer cell samples which are targeted and not targeted with these radiosensitizers are irradiated with 2Gy single fractionated dose. Results obtained shows that the cancer cells which are not targeted with radiosensitizers has a cell viability of 98.80±0.37% after a time interval of 48 hours and has even repopulated over 100% after a 72 hour time interval. This shows that the cancer cells are resistant towards radiation. However, when the cancer cells are targeted with radiosensitizers prior to irradiation, there is a reduction of cell viability by 25.50±10.81% and 10.30±5.10% at time intervals of 48 and 72 hours respectively. This indicates that through the use of these radiosensitizers, cancer cells are more sensitive towards radiation.
AB - Cancer cells which are large in size are resistant towards radiation therapy due to the presence of large amount of anti-oxidative enzymes and hypoxic cancer cells. Thus radiosensitizer agents have been developed to enhance the therapeutic effect of radiotherapy by increasing the sensitivity of these cancer cells towards radiation. This study is conducted to investigate the radiosensitization properties of radiosensitizer complex containing hydrogen peroxide and sodium hyaluronate. Combination with sodium hyaluronate may decrease reactivity of hydrogen peroxide but maintain the oxygen concentration needed for radiosensitizing effect. HepG2 cancer cells are cultured as the mean of test subject. Cancer cell samples which are targeted and not targeted with these radiosensitizers are irradiated with 2Gy single fractionated dose. Results obtained shows that the cancer cells which are not targeted with radiosensitizers has a cell viability of 98.80±0.37% after a time interval of 48 hours and has even repopulated over 100% after a 72 hour time interval. This shows that the cancer cells are resistant towards radiation. However, when the cancer cells are targeted with radiosensitizers prior to irradiation, there is a reduction of cell viability by 25.50±10.81% and 10.30±5.10% at time intervals of 48 and 72 hours respectively. This indicates that through the use of these radiosensitizers, cancer cells are more sensitive towards radiation.
KW - Cancer
KW - Cell viability
KW - Radiation
KW - Radiosensitizer
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85063851411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063851411&partnerID=8YFLogxK
U2 - 10.1063/1.4895175
DO - 10.1063/1.4895175
M3 - Conference contribution
AN - SCOPUS:85063851411
T3 - AIP Conference Proceedings
SP - 78
EP - 81
BT - 2014 UKM FST Postgraduate Colloquium - Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium
A2 - Ibrahim, Zahari
A2 - Maideen, Haja Maideen Kader
A2 - Ibrahim, Nazlina
A2 - Karim, Nurul Huda Abd
A2 - Yusof, Taufik
A2 - Razak, Fatimah Abdul
A2 - Maseran, Nurulkamal
A2 - Khalid, Rozida Mohd
A2 - Ibrahim, Noor Baa'yah
A2 - Sidek, Hasidah Mohd.
A2 - Noorani, Mohd Salmi Md
A2 - Simon, Norbert
PB - American Institute of Physics Inc.
ER -