Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents

Hua Li Qin, Jing Leng, Bahaa G M Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi, Bukhari Syed Nasir Abbas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The incidence of cancer can be decreased by chemoprevention using either natural or synthetic agents. Apart from synthetic compounds, numerous natural products have exhibited promising potential to inhibit carcinogenesis in vivo. In this study, α, β-unsaturated carbonyl-based anticancer compounds were used as starting materials to synthesize new oxime analogs. The findings from the antiproliferative assay using seven different human cancer cell lines provided a clear picture of structure-activity relationship. The oxime analogs namely 7a and 8a showed strong antiproliferative activity against the cell lines. The mechanistic effects of compounds on EGFR-TK kinases and tubulin polymerization and BRAFV 600E were investigated. In addition, the efficacy of compounds in reversing the efflux-mediated resistance developed by cancer cells was also studied. The compounds 5a and 6a displayed potent activity on various targets such as BRAFV 600E and EGFR-TK kinases and also exhibited strong antiproliferative activity against different cell lines hence showing potential of multifunctional anticancer agents. Copyright

Original languageEnglish
JournalChemical Biology and Drug Design
DOIs
Publication statusAccepted/In press - 2017
Externally publishedYes

Fingerprint

Curcumin
Oximes
Antineoplastic Agents
Cells
Cell Line
Phosphotransferases
Neoplasms
Chemoprevention
Structure-Activity Relationship
Tubulin
Biological Products
Polymerization
Carcinogenesis
Assays
Incidence

Keywords

  • Epidermal growth factor receptor (EGFR)
  • Multidrug resistance (MDR)
  • Natural compounds
  • Tubulin polymerization
  • α, β-unsaturated carbonyl

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Qin, H. L., Leng, J., Youssif, B. G. M., Amjad, M. W., Raja, M. A. G., Hussain, M. A., ... Syed Nasir Abbas, B. (Accepted/In press). Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents. Chemical Biology and Drug Design. https://doi.org/10.1111/cbdd.12964

Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents. / Qin, Hua Li; Leng, Jing; Youssif, Bahaa G M; Amjad, Muhammad Wahab; Raja, Maria Abdul Ghafoor; Hussain, Muhammad Ajaz; Hussain, Zahid; Kazmi, Syeda Naveed; Syed Nasir Abbas, Bukhari.

In: Chemical Biology and Drug Design, 2017.

Research output: Contribution to journalArticle

Qin, HL, Leng, J, Youssif, BGM, Amjad, MW, Raja, MAG, Hussain, MA, Hussain, Z, Kazmi, SN & Syed Nasir Abbas, B 2017, 'Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents', Chemical Biology and Drug Design. https://doi.org/10.1111/cbdd.12964
Qin, Hua Li ; Leng, Jing ; Youssif, Bahaa G M ; Amjad, Muhammad Wahab ; Raja, Maria Abdul Ghafoor ; Hussain, Muhammad Ajaz ; Hussain, Zahid ; Kazmi, Syeda Naveed ; Syed Nasir Abbas, Bukhari. / Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents. In: Chemical Biology and Drug Design. 2017.
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