Synthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug delivery

Mohd Cairul Iqbal Mohd Amin, Naveed Ahmad, Nadia Halib, Ishak Ahmad

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

To assist in identifying the utility of novel materials in drug-delivery applications, this study investigated the use of bacterial cellulose (BC), a natural biopolymer, in the synthesis of hydrogels for drug-delivery systems. BC was combined with different proportions of acrylic acid (AA) to fabricate hydrogels by exposure to accelerated electron-beam irradiation at different doses. Fourier transform infrared analysis revealed that the AA had been successfully grafted onto the cellulose fibers and allowed for prediction of the reaction mechanism in the synthesis of hydrogels. Thermal and morphological characterization indicated the formation of thermally stable hydrogels with pore size determined by AA content and irradiation dose. The results of swelling and in vitro drug-release studies revealed the hydrogels to be both thermo- and pH-responsive. Such thermo- and pH-responsiveness, in addition to their morphological characteristics, suggests that these BC/AA hydrogels are promising candidates as controlled drug-delivery systems.

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalCarbohydrate Polymers
Volume88
Issue number2
DOIs
Publication statusPublished - 2 Apr 2012

Fingerprint

Hydrogels
Drug delivery
Cellulose
Acrylics
Acids
Dosimetry
Irradiation
Controlled drug delivery
Biopolymers
Pore size
Swelling
acrylic acid
Electron beams
Fourier transforms
Infrared radiation
Fibers
Pharmaceutical Preparations

Keywords

  • Acrylic acid
  • Bacterial cellulose
  • Drug-delivery system
  • Electron-beam irradiation
  • Hydrogel
  • Swelling behavior

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Synthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug delivery. / Mohd Amin, Mohd Cairul Iqbal; Ahmad, Naveed; Halib, Nadia; Ahmad, Ishak.

In: Carbohydrate Polymers, Vol. 88, No. 2, 02.04.2012, p. 465-473.

Research output: Contribution to journalArticle

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