Sintesis dan pencirian kompleks Nikel(II) salfen dengan rantai sisi piperidina dan kajian interaksi dengan DNA denggi

Translated title of the contribution: Synthesis and characterization of Nickel(II) salphen complex with piperidine side chain and interaction study with dengue DNA

Research output: Contribution to journalArticle

Abstract

Development of DNA biosensor model based on interaction of metal complexes as DNA hybridization marker can be used for dengue viruses early diagnosis. Nickel(II) salphen complex with piperidine side chain were successfully synthesized and characterized using Nucleus Magnetic Resonance Spectroscopy (NMR), mass spectrometry, differential scanning calorimetry and FTIR. The binding mode and interactions of nickel(II) salphen complex with piperidine side chain and dengue DNA were determined by UV-vis titration. Based on ultra violet visible spectra, hypochromism and redshift (bathochromism) were observed after upon tiration of the complex with dengue DNA which suggested formation of new complex. Nickel(II) salphen complex with piperidine side chain interact with dengue DNA by intercalation binding mode with the binding constant, Kb= 4.576x105 M-1. This new finding is so valuable for developing nickel(II) salphen complex as DNA hybridization marker for DNA optical biosensor to determine dengue virus.

Original languageMalay
Pages (from-to)1139-1146
Number of pages8
JournalSains Malaysiana
Volume47
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

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Nickel
DNA
Viruses
Biosensors
Magnetic resonance spectroscopy
Coordination Complexes
Intercalation
salphen
piperidine
Titration
Mass spectrometry
Differential scanning calorimetry

ASJC Scopus subject areas

  • General

Cite this

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title = "Sintesis dan pencirian kompleks Nikel(II) salfen dengan rantai sisi piperidina dan kajian interaksi dengan DNA denggi",
abstract = "Development of DNA biosensor model based on interaction of metal complexes as DNA hybridization marker can be used for dengue viruses early diagnosis. Nickel(II) salphen complex with piperidine side chain were successfully synthesized and characterized using Nucleus Magnetic Resonance Spectroscopy (NMR), mass spectrometry, differential scanning calorimetry and FTIR. The binding mode and interactions of nickel(II) salphen complex with piperidine side chain and dengue DNA were determined by UV-vis titration. Based on ultra violet visible spectra, hypochromism and redshift (bathochromism) were observed after upon tiration of the complex with dengue DNA which suggested formation of new complex. Nickel(II) salphen complex with piperidine side chain interact with dengue DNA by intercalation binding mode with the binding constant, Kb= 4.576x105 M-1. This new finding is so valuable for developing nickel(II) salphen complex as DNA hybridization marker for DNA optical biosensor to determine dengue virus.",
keywords = "Dengue DNA, DNA interaction, Nickel(II) salfen complex, Nickel(II) salphen complex characterization",
author = "Ariffin, {Eda Yuhana} and Lee, {Yook Heng} and {Tan @ Chong}, {Ling Ling} and {Abd Karim}, {Nurul Huda}",
year = "2018",
month = "6",
day = "1",
doi = "10.17576/jsm-2018-4706-09",
language = "Malay",
volume = "47",
pages = "1139--1146",
journal = "Sains Malaysiana",
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publisher = "Penerbit Universiti Kebangsaan Malaysia",
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AU - Ariffin, Eda Yuhana

AU - Lee, Yook Heng

AU - Tan @ Chong, Ling Ling

AU - Abd Karim, Nurul Huda

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Development of DNA biosensor model based on interaction of metal complexes as DNA hybridization marker can be used for dengue viruses early diagnosis. Nickel(II) salphen complex with piperidine side chain were successfully synthesized and characterized using Nucleus Magnetic Resonance Spectroscopy (NMR), mass spectrometry, differential scanning calorimetry and FTIR. The binding mode and interactions of nickel(II) salphen complex with piperidine side chain and dengue DNA were determined by UV-vis titration. Based on ultra violet visible spectra, hypochromism and redshift (bathochromism) were observed after upon tiration of the complex with dengue DNA which suggested formation of new complex. Nickel(II) salphen complex with piperidine side chain interact with dengue DNA by intercalation binding mode with the binding constant, Kb= 4.576x105 M-1. This new finding is so valuable for developing nickel(II) salphen complex as DNA hybridization marker for DNA optical biosensor to determine dengue virus.

AB - Development of DNA biosensor model based on interaction of metal complexes as DNA hybridization marker can be used for dengue viruses early diagnosis. Nickel(II) salphen complex with piperidine side chain were successfully synthesized and characterized using Nucleus Magnetic Resonance Spectroscopy (NMR), mass spectrometry, differential scanning calorimetry and FTIR. The binding mode and interactions of nickel(II) salphen complex with piperidine side chain and dengue DNA were determined by UV-vis titration. Based on ultra violet visible spectra, hypochromism and redshift (bathochromism) were observed after upon tiration of the complex with dengue DNA which suggested formation of new complex. Nickel(II) salphen complex with piperidine side chain interact with dengue DNA by intercalation binding mode with the binding constant, Kb= 4.576x105 M-1. This new finding is so valuable for developing nickel(II) salphen complex as DNA hybridization marker for DNA optical biosensor to determine dengue virus.

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KW - Nickel(II) salfen complex

KW - Nickel(II) salphen complex characterization

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