Sintesis dan pencirian poli(etilena glikol) bermetoksi-ko-poli(β-amino ester) yang dibentuk daripada heksilamina linear dan siklik sebagai misel polimer

Translated title of the contribution: Synthesis and characterization of methoxy poly(ethylene glycol)-co-poly(β-amino ester) formed by linear and cyclic hexylamines as polymeric micelles

Jia Chyi Wong, Chin Hua Chia, Swee Yee Chin, Poi Sim Khiew, Sarani Zakaria

Research output: Contribution to journalArticle

Abstract

Methoxy poly(ethylene glycol)-co-poly(β-amino ester) (MPEG-PbAE) was synthesized using pre-modified acrylated-end methoxy poly(ethylene glycol) (MPEG-ac), 1,6-hexanediol diacrylate, linear hexylamine (A) and cyclic hexylamine (B) as reactants. The MPEG-PbAE copolymer A and B were expected to form micelles where MPEG acts as the hydrophilic shell and the PbAE with hexyl groups acts as the hydrophobic core. The modified MPEG-ac, synthesized MPEG-PbAE copolymer A and B were then characterized. The Fourier transformed infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) confirmed the modification of hydroxyl end group of MPEG to acrylate end group. It was found that the copolymer A is more suitable as drug carrier by the comparison between copolymer A formed by linear hexylamine and copolymer B formed by cyclic hexylamine. Gel permeation chromatography (GPC) showed that the number average molecular weight, M OF the copolymer A was 11216 with polydispersity index (PDI) 1.1925. The critical micelle concentration (CMC) of copolymer A in aqueous solution at pH7.4 is 84.6 mg/L. The average micellar size that are obtained from dynamic light scattering (DLS) analysis was 26.25±0.149 nm.

Original languageIndonesian
Pages (from-to)1849-1855
Number of pages7
JournalSains Malaysiana
Volume45
Issue number12
Publication statusPublished - 1 Dec 2016

Fingerprint

Micelles
Polyethylene glycols
Esters
Copolymers
Nuclear magnetic resonance
Drug Carriers
Critical micelle concentration
Gel permeation chromatography
Polydispersity
Dynamic light scattering
monomethoxypolyethylene glycol
hexylamine
Hydroxyl Radical
Nuclear magnetic resonance spectroscopy
Infrared spectroscopy
Molecular weight

Keywords

  • Hexylamine
  • Methoxy poly(ethylene glycol)-co-poly(β-amino ester)
  • Polymeric micelles

ASJC Scopus subject areas

  • General

Cite this

Sintesis dan pencirian poli(etilena glikol) bermetoksi-ko-poli(β-amino ester) yang dibentuk daripada heksilamina linear dan siklik sebagai misel polimer. / Wong, Jia Chyi; Chia, Chin Hua; Chin, Swee Yee; Khiew, Poi Sim; Zakaria, Sarani.

In: Sains Malaysiana, Vol. 45, No. 12, 01.12.2016, p. 1849-1855.

Research output: Contribution to journalArticle

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abstract = "Methoxy poly(ethylene glycol)-co-poly(β-amino ester) (MPEG-PbAE) was synthesized using pre-modified acrylated-end methoxy poly(ethylene glycol) (MPEG-ac), 1,6-hexanediol diacrylate, linear hexylamine (A) and cyclic hexylamine (B) as reactants. The MPEG-PbAE copolymer A and B were expected to form micelles where MPEG acts as the hydrophilic shell and the PbAE with hexyl groups acts as the hydrophobic core. The modified MPEG-ac, synthesized MPEG-PbAE copolymer A and B were then characterized. The Fourier transformed infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) confirmed the modification of hydroxyl end group of MPEG to acrylate end group. It was found that the copolymer A is more suitable as drug carrier by the comparison between copolymer A formed by linear hexylamine and copolymer B formed by cyclic hexylamine. Gel permeation chromatography (GPC) showed that the number average molecular weight, M OF the copolymer A was 11216 with polydispersity index (PDI) 1.1925. The critical micelle concentration (CMC) of copolymer A in aqueous solution at pH7.4 is 84.6 mg/L. The average micellar size that are obtained from dynamic light scattering (DLS) analysis was 26.25±0.149 nm.",
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