Synthesis and characterisation of phenanthroline adducts of Pb(II) complexes of BisN-alkyl-N-ethyldithiocarbamates

Normah Awang, Nadia Atiqah Nordin, Nurlina Rashid, Kamaludin Nurul Farahana

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dithiocarbamates are a class of met al-chelating compounds with various applications in medicine. They have been used for the treatment of bacterial and fungal infections, possible treatment of AIDS, and most recently cancer. Dithiocarbamates are well-known compounds to bind strongly and selectively to many met al ions.Dithiocarbamate ligands readily form chelates with met al ions through its two donor sulphur atoms.A new series ofplumbum(II) complexes with mixed ligands, dithiocarbamate, and 1,10-phenanthroline were successfully synthesised using in situ method. Microelemental analysis data of the complexes were in agreement with the general formula, Pb[S<inf>2</inf>CNR'R"]<inf>3</inf>phen (R' = ethyl, R" = butyl, cyclohexyl; phen = 1,10-phenanthroline). Infrared spectra of the complexes showed that the thioureide v(C-N) band was in the region 1450-1500 cm<sup>-1</sup>. The unsplitting band of v(C-S) in the region 930-1000 cm 1indicated the bidentate nature of the chelated dithiocarbamato ligands. The <sup>13</sup>C NMR chemical shift of the carbon atom of the N-CS2 group appeared in the range of 202-207 ppm.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalOriental Journal of Chemistry
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Mar 2015
Externally publishedYes

Fingerprint

Phenanthrolines
ligand
Ligands
Ions
Atoms
Mycoses
ion
chelate
Chemical shift
acquired immune deficiency syndrome
Chelation
Sulfur
Bacterial Infections
medicine
Medicine
nuclear magnetic resonance
cancer
Acquired Immunodeficiency Syndrome
Carbon
sulfur

Keywords

  • Chemical shift
  • Dithiocarbamate
  • Phenanthroline
  • Plumbum
  • Thioureide

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Drug Discovery

Cite this

Synthesis and characterisation of phenanthroline adducts of Pb(II) complexes of BisN-alkyl-N-ethyldithiocarbamates. / Awang, Normah; Nordin, Nadia Atiqah; Rashid, Nurlina; Nurul Farahana, Kamaludin.

In: Oriental Journal of Chemistry, Vol. 31, No. 1, 01.03.2015, p. 333-339.

Research output: Contribution to journalArticle

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