Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones

M. Ali Hapipah, Siti Nadiah Abdul Halim, Puvaneswary Subramaniam, S. M. Zain, W. Jefri Basirun, Endom Ismail, Noorlidah Abdullah, H. L. Teoh

Research output: Contribution to journalArticle

Abstract

The new zinc(II) complexes have been prepared in ethanol by condensation of 2-hydroxyacetophenone with either benzhydrazide or 3-methoxybenzhydrazide and zinc acetate in the presence of triethylamine. The IR, 1H, 13C NMR and UV-visible data show coordination of hydrazone ligands to the metal centers and the spectroscopic data augur well with the x-ray structures which had been published earlier. The Schiff bases and their complexes were screened for antimicrobial, cytotoxic and antioxidant activities. The anti-microbial activities of the ligands and complexes were evaluated by using plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi. The Schiff base, H2hapbh was cytotoxic with IC50 10-0 μgml-1 against the MCF-7 (human breast cancer cells) while both zinc(II) dimer complexes were strongly cytotoxic with IC50 values of 4.5 μgml-1. The Schiff bases and zinc(II) complexes showed higher antioxidant activity than quercetin or vitamin E and is comparable with butylated hydroxytoluene (BHT), a commercially used synthetic antioxidant.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalMalaysian Journal of Science
Volume25
Issue number2
Publication statusPublished - Dec 2006

Fingerprint

Schiff Bases
Zinc
Bacteria
Antioxidants
Ligands
Fungi
Zinc Acetate
Hydrazones
Butylated Hydroxytoluene
Quercetin
Vitamin E
Dimers
Condensation
Ethanol
Metals
Cells
Nuclear magnetic resonance
X rays
2-hydroxyacetophenone benzoylhydrazone

Keywords

  • Antioxidant and antimicrobial activities
  • Cytotoxicity
  • Hydrazone Schiff bases
  • Zinc (II) complexes

ASJC Scopus subject areas

  • General

Cite this

Hapipah, M. A., Nadiah Abdul Halim, S., Subramaniam, P., Zain, S. M., Basirun, W. J., Ismail, E., ... Teoh, H. L. (2006). Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones. Malaysian Journal of Science, 25(2), 97-106.

Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones. / Hapipah, M. Ali; Nadiah Abdul Halim, Siti; Subramaniam, Puvaneswary; Zain, S. M.; Basirun, W. Jefri; Ismail, Endom; Abdullah, Noorlidah; Teoh, H. L.

In: Malaysian Journal of Science, Vol. 25, No. 2, 12.2006, p. 97-106.

Research output: Contribution to journalArticle

Hapipah, MA, Nadiah Abdul Halim, S, Subramaniam, P, Zain, SM, Basirun, WJ, Ismail, E, Abdullah, N & Teoh, HL 2006, 'Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones', Malaysian Journal of Science, vol. 25, no. 2, pp. 97-106.
Hapipah MA, Nadiah Abdul Halim S, Subramaniam P, Zain SM, Basirun WJ, Ismail E et al. Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones. Malaysian Journal of Science. 2006 Dec;25(2):97-106.
Hapipah, M. Ali ; Nadiah Abdul Halim, Siti ; Subramaniam, Puvaneswary ; Zain, S. M. ; Basirun, W. Jefri ; Ismail, Endom ; Abdullah, Noorlidah ; Teoh, H. L. / Synthesis and biological properties of zinc(II) complexes of some 2-hydroxyacetophenone-benzoylhydrazones. In: Malaysian Journal of Science. 2006 ; Vol. 25, No. 2. pp. 97-106.
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