Synthesis and biological evaluation of chalcone derivatives (mini review)

Bukhari Syed Nasir Abbas, Malina Jasamai, Ibrahim Jantan

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. A three carbon α, β-unsaturated carbonyl system constitutes chalcones. Chalcones are the condensation products of aromatic aldehyde with acetophenones in attendance of catalyst. They go through an assortment of chemical reactions and are found advantageous in synthesis of pyrazoline, isoxazole and a variety of heterocyclic compounds. In synthesizing a range of therapeutic compounds, chalcones impart key role. They have showed worth mentioning therapeutic efficacy for the treatment of various diseases. Chalcone based derivatives have gained heed since they own simple structures, and diverse pharmacological actions. A lot of methods and schemes have been reported for the synthesis of these compounds. Amongst all, Aldol condensation and Claisen-Schmidt condensation still grasp high up position. Other distinguished techniques include Suzuki reaction, Witting reaction, Friedel-Crafts acylation with cinnamoyl chloride, Photo-Fries rearrangement of phenyl cinnamates etc. These inventive techniques utilize various catalysts and reagents including SOCl2 natural phosphate, lithium nitrate, amino grafted zeolites, zinc oxide, water, Na2CO3, PEG400, silicasulfuric acid, ZrCl4 and ionic liquid etc. The development of better techniques for the synthesis of α, β- unsaturated carbonyl compounds is still in high demand. In brief, we have explained the methods and catalysts used in the synthesis of chalcones along with their biological activities in a review form to provide information for the development of new-fangled processes targeting better yield, less reaction time and least side effects with utmost pharmacological properties.

Original languageEnglish
Pages (from-to)1394-1403
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume12
Issue number13
DOIs
Publication statusPublished - 2012

Fingerprint

Chalcones
Chalcone
Acetophenones
Cinnamates
Pharmacology
Zinc Oxide
Isoxazoles
Heterocyclic Compounds
Zeolites
Ionic Liquids
Acylation
Lithium
Flavonoids
Aldehydes
Nitrates
Carbon
Phosphates
Acids
Water
Therapeutics

Keywords

  • Anti-inflammatory
  • Anticancer
  • Chalcones
  • Claisen-Schmidt condensation
  • Flavonoids

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Synthesis and biological evaluation of chalcone derivatives (mini review). / Syed Nasir Abbas, Bukhari; Jasamai, Malina; Jantan, Ibrahim.

In: Mini-Reviews in Medicinal Chemistry, Vol. 12, No. 13, 2012, p. 1394-1403.

Research output: Contribution to journalArticle

Syed Nasir Abbas, Bukhari ; Jasamai, Malina ; Jantan, Ibrahim. / Synthesis and biological evaluation of chalcone derivatives (mini review). In: Mini-Reviews in Medicinal Chemistry. 2012 ; Vol. 12, No. 13. pp. 1394-1403.
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