Synthesis and biological activities of Nickel(II) and Cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone

Mechanism for formation of the Nickel(II) complex

Mohd Ali Hapipah, Siti Nadiah Abdul Halim, Puvaneswary Subramaniam, Sharifudin M. Zain, Endom Ismail

Research output: Contribution to journalArticle

Abstract

The new Nickel(II) and Cadmium(II) complexes have been prepared in ethanol by template condensation of 4-nitrobenzhydrazide, 5-chloro-2-hydroxyacetophenone and metal acetate in the presence of triethylamine. The IR and UV spectra of the ligand and complexes indicate coordination of ligands to the metal centers. The initial product of the Nickel(II) complex is a square planar compound and upon recrydallization with pyridine, the complex has changed to octahedral geometry with coordination of the solvent molecules. The Schiff base ligand, H25-Clhap-4-NO2bh was more sensitive towards the MCF-7 cells (human breast cancer cells) with IC50 values of 4.5 μg ml-1 than the unsubstituted ligand, H2hapbh. However upon coordination to nickel, the activity has been reduced to the same level as the positive control drug, tamoxifen. The antioxidant properties of the Schiff base ligand (using the FTC method) exhibited higher activity than vitamin E or quercetine. However the activity is lower than the unsubstituted Schiff base ligand or the commercial antioxidant agent, BHT (butylated hydroxytoluene).

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalMalaysian Journal of Science
Volume25
Issue number1
Publication statusPublished - Jun 2006

Fingerprint

Bioactivity
Nickel
Cadmium
Ligands
Schiff Bases
Antioxidants
Metals
Butylated Hydroxytoluene
Tamoxifen
Vitamin E
Condensation
Acetates
Ethanol
Cells
Molecules
Geometry
Pharmaceutical Preparations

Keywords

  • Antioxidant and cytotoxicity properties
  • Mechanism
  • Metal complexes
  • Schiff base

ASJC Scopus subject areas

  • General

Cite this

Synthesis and biological activities of Nickel(II) and Cadmium(II) complexes of chlorohydroxyacetophenone-nitrobenzoylhydrazone : Mechanism for formation of the Nickel(II) complex. / Hapipah, Mohd Ali; Abdul Halim, Siti Nadiah; Subramaniam, Puvaneswary; Zain, Sharifudin M.; Ismail, Endom.

In: Malaysian Journal of Science, Vol. 25, No. 1, 06.2006, p. 99-105.

Research output: Contribution to journalArticle

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