Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene

Emad Yousif, Eva Rentschler, Nadia Salih, Jumat Salimon, Ayad Hameed, Mustafa Katan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the present study, novel tetra Schiff bases were synthesized by condensation of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes. The chemical structures were confirmed by means of IR, 1H NMR, 13C NMR, and elemental analysis. All compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC-25922, and Pseudomonas aeruginosa ATCC-2853) and antifungal (Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique. The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method. Among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole-2-yl]benzene 7 was found to be the most potent antimicrobial activity with MICs of 3.4, 2.1, 1.2, 2.0, 3.1, 2.4, 1.1, and 1.7μg/mL against the above mentioned respective strains.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalJournal of Saudi Chemical Society
Volume18
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

2-amino-1,3,4-thiadiazole
Schiff Bases
Aspergillus
Benzene
Screening
Nuclear magnetic resonance
Bacillus cereus
Aldehydes
Escherichia coli
Dilution
Agar
Condensation
Chemical analysis

Keywords

  • 1,3,4-Thiadiazole
  • Antibacterial
  • Antifungal
  • Tetra Schiff base

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene. / Yousif, Emad; Rentschler, Eva; Salih, Nadia; Salimon, Jumat; Hameed, Ayad; Katan, Mustafa.

In: Journal of Saudi Chemical Society, Vol. 18, No. 3, 2014, p. 269-275.

Research output: Contribution to journalArticle

Yousif, Emad ; Rentschler, Eva ; Salih, Nadia ; Salimon, Jumat ; Hameed, Ayad ; Katan, Mustafa. / Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene. In: Journal of Saudi Chemical Society. 2014 ; Vol. 18, No. 3. pp. 269-275.
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AU - Katan, Mustafa

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AB - In the present study, novel tetra Schiff bases were synthesized by condensation of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes. The chemical structures were confirmed by means of IR, 1H NMR, 13C NMR, and elemental analysis. All compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC-25922, and Pseudomonas aeruginosa ATCC-2853) and antifungal (Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique. The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method. Among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole-2-yl]benzene 7 was found to be the most potent antimicrobial activity with MICs of 3.4, 2.1, 1.2, 2.0, 3.1, 2.4, 1.1, and 1.7μg/mL against the above mentioned respective strains.

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