Synthesis and antimicrobial evaluation of 5-(p-substituted phenyl)-N-(3-(5-nitrofur-2-yl) allylidene)-1,3,4-thiadiazol-2-amine derivatives

Nadia Salih, Jumat Salimon, Emad Yousif

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

5-(p-Substituted phenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4- thiadiazol-2-amines 10-17 were prepared utilizing different p-substituted benzoic acid through two step reactions. Firstly, thiosemicarbzide was reacted with benzoic acid derivatives 1 in the presence of phosphorus oxychloride to give 2-amino-5-substituted-1,3,4-thiadiazoles 2-9. These compounds were reacted with 5-nitrc-2-furanacrolein to yield the target products. The structures of synthesized compounds were confirmed on the basis of their elemental analysis, spectral results (IF), 1H and 13C NMR) and mass spectra. The synthesized compounds were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.

Original languageEnglish
Pages (from-to)373-383
Number of pages11
JournalOriental Journal of Chemistry
Volume27
Issue number2
Publication statusPublished - Apr 2011

Fingerprint

Benzoic Acid
antimicrobial activity
Amines
Derivatives
acid
spectral analysis
nuclear magnetic resonance
Nuclear magnetic resonance
phosphorus
Chemical analysis
evaluation
amine
1,3,4-thiadiazole
phosphoryl chloride
product
Carbon-13 Magnetic Resonance Spectroscopy
Proton Magnetic Resonance Spectroscopy

Keywords

  • 1,3,4-thiadiazole
  • 5-nitro-2-furanacrolein
  • Antimicrobial activity
  • Schiff base

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Drug Discovery

Cite this

Synthesis and antimicrobial evaluation of 5-(p-substituted phenyl)-N-(3-(5-nitrofur-2-yl) allylidene)-1,3,4-thiadiazol-2-amine derivatives. / Salih, Nadia; Salimon, Jumat; Yousif, Emad.

In: Oriental Journal of Chemistry, Vol. 27, No. 2, 04.2011, p. 373-383.

Research output: Contribution to journalArticle

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