Synthesis and antimicrobial activity of 1-(5-mercapto-1,3,4-oxadiazol-2-yl) -2-(pyridine-2-ylamino)ethanone

Jumat Salimon, Nadia Salih, Hasan Hussien

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1-(5-Mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone (3), has been synthesized from 2-(pyridine-2-ylamino)acetohydrazide (2). A yellow colored compound (2) was reacted with carbon disulfide and potassium hydroxide in absolute ethanol to obtain the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2- (pyridine-2-ylamino)ethanone. Structures of the synthesized compounds were supported by means of IR, NMR, MS spectroscopic and elemental analysis. The synthesized compounds were evaluated for their antimicrobial activity and were expressed as the corresponding minimum inhibitory concentration (MIC). A brown colored compound (3) with 90% yield has been successfully synthesized. This compound was found to have significant antimicrobial activity with MIC value ranging from 30.2-43.2 μg cm-3. The findings of the present study indicate that cyclization of hydrazide acid group of 2-(pyridine-2-ylamino) acetohydrazide (2) into 1,3,4-oxadiazole nucleus resulted in increased antimicrobial activity.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalSains Malaysiana
Volume40
Issue number5
Publication statusPublished - May 2011

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Carbon Disulfide
Spectroscopic analysis
Cyclization
Ethanol
Nuclear magnetic resonance
Acids
pyridine
Chemical analysis
potassium hydroxide
1,3,4-oxadiazole

Keywords

  • 1,3,4-oxadiazoles compound
  • Antimicrobial activity
  • Hydrazide acid

ASJC Scopus subject areas

  • General

Cite this

Synthesis and antimicrobial activity of 1-(5-mercapto-1,3,4-oxadiazol-2-yl) -2-(pyridine-2-ylamino)ethanone. / Salimon, Jumat; Salih, Nadia; Hussien, Hasan.

In: Sains Malaysiana, Vol. 40, No. 5, 05.2011, p. 445-450.

Research output: Contribution to journalArticle

Salimon, Jumat ; Salih, Nadia ; Hussien, Hasan. / Synthesis and antimicrobial activity of 1-(5-mercapto-1,3,4-oxadiazol-2-yl) -2-(pyridine-2-ylamino)ethanone. In: Sains Malaysiana. 2011 ; Vol. 40, No. 5. pp. 445-450.
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