Sintesis dan Kajian Antimikrob Terhadap Sebelas Terbitan Maleimida

Translated title of the contribution: Synthesis and antimicrobial activities of eleven n-substituted maleimides

Tang Sook Chin, Fatin Ilyani Nasir, Nurul Izzaty Hassan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The antimicrobial activities of eleven maleimide derivatives were tested in this study. Out of the eleven samples, N-(4-fluorophenyl) maleimide, N-(4-chlorophenyl) maleimide and N-(4-bromophenyl) maleimide were synthesized by reacting maleic anhydride with 4-fluorophenylaniline, 4-chlorophenylaniline and 4-bromophenylaniline, respectively in the presence of acetic acid, by refluxing overnight. Crystals were successfully obtained after the products were recrystallized with different mixture of solvents. Their chemical structures were confirmed by infrared spectroscopy (IR), 1H and 13C Nuclear Magnetic Resonance (NMR) and melting point determination. Subsequently, all the samples were screened for their biological activity using disc diffusion method. The bacteria chosen for this study were Gram-negative Escherichia coli, Gram-positive Bacillus subtilis and yeast Saccharomyces cerevisae. Positive control for bacteria was streptomycin and nystatin for the yeast. M1 to M6 compounds gave remarkable result at low concentrations whereas M8, M9 and M11 compounds are mostly inactive up to a high concentration. In contrast, the unsubstituted maleimide, M7 was highly reactive towards both bacteria and yeast at low and high concentrations.

Original languageMalay
Pages (from-to)741-750
Number of pages10
JournalMalaysian Journal of Analytical Sciences
Volume20
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Maleimides
Yeast
Bacteria
Maleic Anhydrides
Nystatin
Streptomycin
Bacilli
Bioactivity
Acetic Acid
Escherichia coli
Melting point
Infrared spectroscopy
Nuclear magnetic resonance
Derivatives
Crystals
maleimide

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Sintesis dan Kajian Antimikrob Terhadap Sebelas Terbitan Maleimida. / Chin, Tang Sook; Nasir, Fatin Ilyani; Hassan, Nurul Izzaty.

In: Malaysian Journal of Analytical Sciences, Vol. 20, No. 4, 2016, p. 741-750.

Research output: Contribution to journalArticle

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