Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate

D. Kartina, A. W. Wahab, A. Ahmad, I. Raya, B. M. Yamin

Research output: Contribution to journalConference article

Abstract

Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an 'in situ' method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π∗ of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.

Original languageEnglish
Article number32033
JournalJournal of Physics: Conference Series
Volume1341
Issue number3
DOIs
Publication statusPublished - 7 Nov 2019
Event3rd International Conference on Science, ICOS 2019 - Makassar, India
Duration: 26 Jul 201927 Jul 2019

Fingerprint

tuberculosis
phenylalanine
synthesis
drugs
complex compounds
bioassay
ligands
infectious diseases
death
bacteria
infrared absorption
health
melting points
ethyl alcohol
absorption spectra
conductivity
electronics

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate. / Kartina, D.; Wahab, A. W.; Ahmad, A.; Raya, I.; Yamin, B. M.

In: Journal of Physics: Conference Series, Vol. 1341, No. 3, 32033, 07.11.2019.

Research output: Contribution to journalConference article

Kartina, D. ; Wahab, A. W. ; Ahmad, A. ; Raya, I. ; Yamin, B. M. / Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate. In: Journal of Physics: Conference Series. 2019 ; Vol. 1341, No. 3.
@article{e980d6e881db41ca8698d6664d6ea640,
title = "Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate",
abstract = "Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an 'in situ' method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π∗ of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.",
author = "D. Kartina and Wahab, {A. W.} and A. Ahmad and I. Raya and Yamin, {B. M.}",
year = "2019",
month = "11",
day = "7",
doi = "10.1088/1742-6596/1341/3/032033",
language = "English",
volume = "1341",
journal = "Journal of Physics: Conference Series",
issn = "1742-6588",
publisher = "IOP Publishing Ltd.",
number = "3",

}

TY - JOUR

T1 - Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate

AU - Kartina, D.

AU - Wahab, A. W.

AU - Ahmad, A.

AU - Raya, I.

AU - Yamin, B. M.

PY - 2019/11/7

Y1 - 2019/11/7

N2 - Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an 'in situ' method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π∗ of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.

AB - Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an 'in situ' method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π∗ of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.

UR - http://www.scopus.com/inward/record.url?scp=85074993774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074993774&partnerID=8YFLogxK

U2 - 10.1088/1742-6596/1341/3/032033

DO - 10.1088/1742-6596/1341/3/032033

M3 - Conference article

AN - SCOPUS:85074993774

VL - 1341

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

SN - 1742-6588

IS - 3

M1 - 32033

ER -