Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria

Siti Nurazwa Zainol, Shahida Mohd Said, Zamirah Zainal Abidin, Nuramirah Azizan, Fadzilah Adibah Abdul Majid, Ibrahim Jantan

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Eugenia caryophyllata L. and Cinnamomum zeylanicum Blume essential oils offer great potential against the pathogens of oral cavity. Both of these essential oils have recently being used as antibiotics and antiviral agents. This study investigates the synergistic effect of E. caryophyllata and C. zeylanicum oils against known resistant bacteria in oral infection namely Enterococcus faecalis, Aggregatibacter actinomycetemcomitans, Streptococcus mutan and Streptococcus salivarius. The combination effect E. caryophyllata and C. zeylanicum were evaluated using checkerboard assays. Amoxicillin at concentration 0.1 mg/mL was used as positive control while each bacteria suspension (105 CFU/mL) was used as negative control. The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FIC) were calculated to characterised interaction between the combinations. Both E. caryophyllata and C. zeylanicum oils possess antimicrobial activity against all the four bacteria when used on its own or in combination. In combination, the MIC values were reduced for all bacteria compared when in single form. The synergistic antibacterial effect was significant toward E. faecalis, A. actinomycetemcomitans and S. mutans with FIC index is 0.5 and below. Partial synergy was produced in S.salivarus. The acceptable range for synergistic effect is between 0.16 mg/mL and 0.31 mg/mL. Above from 0.63 mg/mL are considered as additive and antagonistic effect. The combinations of these essential oils gave a stronger antibacterial activity and directly can replace the common use of antibiotics like Amoxicillin. This finding suggests a potential therapeutic benefit using the combination of E. caryophyllata and C. zeylanicum oils in the future management of oral infection.

Original languageEnglish
Title of host publicationChemical Engineering Transactions
PublisherItalian Association of Chemical Engineering - AIDIC
Pages1429-1434
Number of pages6
Volume56
ISBN (Electronic)9788895608471
DOIs
Publication statusPublished - 2017

Publication series

NameChemical Engineering Transactions
Volume56
ISSN (Electronic)2283-9216

Fingerprint

Essential oils
Volatile Oils
Bacteria
Oils
Amoxicillin
Antibiotics
Antiviral agents
Anti-Bacterial Agents
Pathogens
Antiviral Agents
Assays
Suspensions

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Zainol, S. N., Mohd Said, S., Zainal Abidin, Z., Azizan, N., Majid, F. A. A., & Jantan, I. (2017). Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. In Chemical Engineering Transactions (Vol. 56, pp. 1429-1434). (Chemical Engineering Transactions; Vol. 56). Italian Association of Chemical Engineering - AIDIC. https://doi.org/10.3303/CET1756239

Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. / Zainol, Siti Nurazwa; Mohd Said, Shahida; Zainal Abidin, Zamirah; Azizan, Nuramirah; Majid, Fadzilah Adibah Abdul; Jantan, Ibrahim.

Chemical Engineering Transactions. Vol. 56 Italian Association of Chemical Engineering - AIDIC, 2017. p. 1429-1434 (Chemical Engineering Transactions; Vol. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

Zainol, SN, Mohd Said, S, Zainal Abidin, Z, Azizan, N, Majid, FAA & Jantan, I 2017, Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. in Chemical Engineering Transactions. vol. 56, Chemical Engineering Transactions, vol. 56, Italian Association of Chemical Engineering - AIDIC, pp. 1429-1434. https://doi.org/10.3303/CET1756239
Zainol SN, Mohd Said S, Zainal Abidin Z, Azizan N, Majid FAA, Jantan I. Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. In Chemical Engineering Transactions. Vol. 56. Italian Association of Chemical Engineering - AIDIC. 2017. p. 1429-1434. (Chemical Engineering Transactions). https://doi.org/10.3303/CET1756239
Zainol, Siti Nurazwa ; Mohd Said, Shahida ; Zainal Abidin, Zamirah ; Azizan, Nuramirah ; Majid, Fadzilah Adibah Abdul ; Jantan, Ibrahim. / Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. Chemical Engineering Transactions. Vol. 56 Italian Association of Chemical Engineering - AIDIC, 2017. pp. 1429-1434 (Chemical Engineering Transactions).
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