Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology

Zakiyah Zain, Nazrina Aziz, Yuhaniz Ahmad, Zairul Azwan, Farhana Raduan, Ismail Sagap

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Colorectal cancer is the third and the second most common cancer worldwide in men and women respectively, and the second in Malaysia for both genders. Surgery, chemotherapy and radiotherapy are among the options available for treatment of patients with colorectal cancer. In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments. Treatment comparisons often involve several responses or endpoints, and this situation complicates the analysis. In the case of colorectal cancer, sets of responses concerned with survival times include: times from tumor removal until the first, the second and the third tumor recurrences, and time to death. For a patient, the time to recurrence is correlated to the overall survival. In this study, global score test methodology is used in combining the univariate score statistics for comparing treatments with respect to each survival endpoint into a single statistic. The data of tumor recurrence and overall survival of colorectal cancer patients are taken from a Malaysian hospital. The results are found to be similar to those computed using the established Wei, Lin and Weissfeld method. Key factors such as ethnic, gender, age and stage at diagnose are also reported.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
Pages956-961
Number of pages6
Volume1635
ISBN (Print)9780735412743
DOIs
Publication statusPublished - 2014
Event3rd International Conference on Quantitative Sciences and Its Applications: Fostering Innovation, Streamlining Development, ICOQSIA 2014 - Langkawi, Kedah
Duration: 12 Aug 201414 Aug 2014

Other

Other3rd International Conference on Quantitative Sciences and Its Applications: Fostering Innovation, Streamlining Development, ICOQSIA 2014
CityLangkawi, Kedah
Period12/8/1414/8/14

Fingerprint

tumors
cancer
methodology
statistics
Malaysia
chemotherapy
death
surgery
radiation therapy

Keywords

  • colorectal cancer
  • recurrence
  • score test
  • Survival analysis
  • Wei Lin and Weissfeld

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Zain, Z., Aziz, N., Ahmad, Y., Azwan, Z., Raduan, F., & Sagap, I. (2014). Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology. In AIP Conference Proceedings (Vol. 1635, pp. 956-961). American Institute of Physics Inc.. https://doi.org/10.1063/1.4903697

Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology. / Zain, Zakiyah; Aziz, Nazrina; Ahmad, Yuhaniz; Azwan, Zairul; Raduan, Farhana; Sagap, Ismail.

AIP Conference Proceedings. Vol. 1635 American Institute of Physics Inc., 2014. p. 956-961.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zain, Z, Aziz, N, Ahmad, Y, Azwan, Z, Raduan, F & Sagap, I 2014, Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology. in AIP Conference Proceedings. vol. 1635, American Institute of Physics Inc., pp. 956-961, 3rd International Conference on Quantitative Sciences and Its Applications: Fostering Innovation, Streamlining Development, ICOQSIA 2014, Langkawi, Kedah, 12/8/14. https://doi.org/10.1063/1.4903697
Zain Z, Aziz N, Ahmad Y, Azwan Z, Raduan F, Sagap I. Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology. In AIP Conference Proceedings. Vol. 1635. American Institute of Physics Inc. 2014. p. 956-961 https://doi.org/10.1063/1.4903697
Zain, Zakiyah ; Aziz, Nazrina ; Ahmad, Yuhaniz ; Azwan, Zairul ; Raduan, Farhana ; Sagap, Ismail. / Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology. AIP Conference Proceedings. Vol. 1635 American Institute of Physics Inc., 2014. pp. 956-961
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