Surgical treatment of endocrine hypertension: Experience in Malaysia

F. A. Meah, A. Taha, K. S. Tay, A. Noor Hisham, A. K. Khalid, T. T. Tan

    Research output: Contribution to journalArticle

    Abstract

    Between January 1978 and December 1992, 110 cases of endocrine-based hypertension were diagnosed and treated surgically at the National University of Malaysia. Fifty-two cases (47.3%) had Conn's syndrome, 38 cases (34.6%) had Cushing's syndrome and 20 cases (18.1%) had pheochromocytoma. The most common cause of Conn's syndrome was Conn's adenoma (96%) which arose mainly from the left adrenal gland (73%). Cushing's syndrome was caused by adrenocortical adenoma (42%), diffuse bilateral adrenal hyperplasia (35%), pigmented macronodular hyperplasia (15%) or adrenal carcinoma (8%). In pheochromocytoma, 75% of the tumours arose from the adrenal glands and 25% arose from the extra adrenal tissue. The tumours removed were benign and unassociated with multiple endocrine neoplasia. In our series, the success rate of surgical treatment was 94% for Conn's syndrome, 100% for pheochromocytoma and 97% for Cushing's syndrome. Four (6%) patients with Conn's syndrome who remained hypertensive required only one antihypertension drug. Trucut biopsy of the kidneys of these patients showed hypertensive changes; the moderate hypertension could be due to renal damage. The successful treatment of endocrine hypertension needs the combined efforts of the endocrinologist, surgeon and anaesthetist.

    Original languageEnglish
    Pages (from-to)127-133
    Number of pages7
    JournalAsian Journal of Surgery
    Volume17
    Issue number2
    Publication statusPublished - 1994

    Fingerprint

    Hyperaldosteronism
    Malaysia
    Cushing Syndrome
    Pheochromocytoma
    Adrenocortical Adenoma
    Hypertension
    Adrenal Glands
    Hyperplasia
    Multiple Endocrine Neoplasia
    Kidney
    Therapeutics
    Neoplasms
    Carcinoma
    Biopsy
    Pharmaceutical Preparations

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Meah, F. A., Taha, A., Tay, K. S., Noor Hisham, A., Khalid, A. K., & Tan, T. T. (1994). Surgical treatment of endocrine hypertension: Experience in Malaysia. Asian Journal of Surgery, 17(2), 127-133.

    Surgical treatment of endocrine hypertension : Experience in Malaysia. / Meah, F. A.; Taha, A.; Tay, K. S.; Noor Hisham, A.; Khalid, A. K.; Tan, T. T.

    In: Asian Journal of Surgery, Vol. 17, No. 2, 1994, p. 127-133.

    Research output: Contribution to journalArticle

    Meah, FA, Taha, A, Tay, KS, Noor Hisham, A, Khalid, AK & Tan, TT 1994, 'Surgical treatment of endocrine hypertension: Experience in Malaysia', Asian Journal of Surgery, vol. 17, no. 2, pp. 127-133.
    Meah FA, Taha A, Tay KS, Noor Hisham A, Khalid AK, Tan TT. Surgical treatment of endocrine hypertension: Experience in Malaysia. Asian Journal of Surgery. 1994;17(2):127-133.
    Meah, F. A. ; Taha, A. ; Tay, K. S. ; Noor Hisham, A. ; Khalid, A. K. ; Tan, T. T. / Surgical treatment of endocrine hypertension : Experience in Malaysia. In: Asian Journal of Surgery. 1994 ; Vol. 17, No. 2. pp. 127-133.
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