Suppression of atherogenesis in cholesterol-fed rabbits treated with nicardipine

Kamsiah Jaarin, M. I. Nafeeza, A. C. Ngang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of nicardipine on the suppression of atherosclerosis were studied. Twelve rabbits were fed with a 2% cholesterol (atherogenic) diet and 6 of these rabbits were given nicardipine 0.5 mg kg-1 twice daily intramuscularly for 10 weeks, while the remaining 6 did not receive any treatment. Another 6 rabbits, given a standard diet, were used as controls. At 4 and 8 weeks, the difference in the fasting serum cholesterol and serum calcium levels between rabbits on the atherogenic diet with nicardipine and those on the atherogenic diet without nicardipine were not significant. However, the aortic total cholesterol and calcium contents (measured at 10 weeks of study) were significantly lowered (P < 0.01) in rabbits on the atherogenic diet with nicardipine. The area of Sudan IV positive intimal lesions in the aorta were also decreased significantly (P < 0.01) in the same group. These findings suggest that nicardipine suppressed atherogenesis without reducing serum cholesterol level.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalAsia Pacific Journal of Pharmacology
Volume9
Issue number3
Publication statusPublished - 1994

Fingerprint

Nicardipine
Atherogenic Diet
Atherosclerosis
Cholesterol
Rabbits
Serum
Tunica Intima
Calcium
Aorta
Fasting
Diet

Keywords

  • atherosclerosis
  • calcium entry blocker
  • cholesterol-feeding

ASJC Scopus subject areas

  • Pharmacology

Cite this

Suppression of atherogenesis in cholesterol-fed rabbits treated with nicardipine. / Jaarin, Kamsiah; Nafeeza, M. I.; Ngang, A. C.

In: Asia Pacific Journal of Pharmacology, Vol. 9, No. 3, 1994, p. 183-187.

Research output: Contribution to journalArticle

@article{a29d495307a5448fa1c61df7ba032a6b,
title = "Suppression of atherogenesis in cholesterol-fed rabbits treated with nicardipine",
abstract = "The effects of nicardipine on the suppression of atherosclerosis were studied. Twelve rabbits were fed with a 2{\%} cholesterol (atherogenic) diet and 6 of these rabbits were given nicardipine 0.5 mg kg-1 twice daily intramuscularly for 10 weeks, while the remaining 6 did not receive any treatment. Another 6 rabbits, given a standard diet, were used as controls. At 4 and 8 weeks, the difference in the fasting serum cholesterol and serum calcium levels between rabbits on the atherogenic diet with nicardipine and those on the atherogenic diet without nicardipine were not significant. However, the aortic total cholesterol and calcium contents (measured at 10 weeks of study) were significantly lowered (P < 0.01) in rabbits on the atherogenic diet with nicardipine. The area of Sudan IV positive intimal lesions in the aorta were also decreased significantly (P < 0.01) in the same group. These findings suggest that nicardipine suppressed atherogenesis without reducing serum cholesterol level.",
keywords = "atherosclerosis, calcium entry blocker, cholesterol-feeding",
author = "Kamsiah Jaarin and Nafeeza, {M. I.} and Ngang, {A. C.}",
year = "1994",
language = "English",
volume = "9",
pages = "183--187",
journal = "Asia Pacific Journal of Pharmacology",
issn = "0217-9687",
publisher = "Singapore University Press",
number = "3",

}

TY - JOUR

T1 - Suppression of atherogenesis in cholesterol-fed rabbits treated with nicardipine

AU - Jaarin, Kamsiah

AU - Nafeeza, M. I.

AU - Ngang, A. C.

PY - 1994

Y1 - 1994

N2 - The effects of nicardipine on the suppression of atherosclerosis were studied. Twelve rabbits were fed with a 2% cholesterol (atherogenic) diet and 6 of these rabbits were given nicardipine 0.5 mg kg-1 twice daily intramuscularly for 10 weeks, while the remaining 6 did not receive any treatment. Another 6 rabbits, given a standard diet, were used as controls. At 4 and 8 weeks, the difference in the fasting serum cholesterol and serum calcium levels between rabbits on the atherogenic diet with nicardipine and those on the atherogenic diet without nicardipine were not significant. However, the aortic total cholesterol and calcium contents (measured at 10 weeks of study) were significantly lowered (P < 0.01) in rabbits on the atherogenic diet with nicardipine. The area of Sudan IV positive intimal lesions in the aorta were also decreased significantly (P < 0.01) in the same group. These findings suggest that nicardipine suppressed atherogenesis without reducing serum cholesterol level.

AB - The effects of nicardipine on the suppression of atherosclerosis were studied. Twelve rabbits were fed with a 2% cholesterol (atherogenic) diet and 6 of these rabbits were given nicardipine 0.5 mg kg-1 twice daily intramuscularly for 10 weeks, while the remaining 6 did not receive any treatment. Another 6 rabbits, given a standard diet, were used as controls. At 4 and 8 weeks, the difference in the fasting serum cholesterol and serum calcium levels between rabbits on the atherogenic diet with nicardipine and those on the atherogenic diet without nicardipine were not significant. However, the aortic total cholesterol and calcium contents (measured at 10 weeks of study) were significantly lowered (P < 0.01) in rabbits on the atherogenic diet with nicardipine. The area of Sudan IV positive intimal lesions in the aorta were also decreased significantly (P < 0.01) in the same group. These findings suggest that nicardipine suppressed atherogenesis without reducing serum cholesterol level.

KW - atherosclerosis

KW - calcium entry blocker

KW - cholesterol-feeding

UR - http://www.scopus.com/inward/record.url?scp=0027987411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027987411&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 183

EP - 187

JO - Asia Pacific Journal of Pharmacology

JF - Asia Pacific Journal of Pharmacology

SN - 0217-9687

IS - 3

ER -